tetano
Editor, Senior Moderator
Eur J Med Chem
. 2022 Feb 4;232:114175.
doi: 10.1016/j.ejmech.2022.114175. Online ahead of print.
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy
Aurelia Magdalena Pisoschi[SUP] 1 [/SUP], Aneta Pop[SUP] 2 [/SUP], Florin Iordache[SUP] 2 [/SUP], Loredana Stanca[SUP] 2 [/SUP], Ovidiu Ionut Geicu[SUP] 2 [/SUP], Liviu Bilteanu[SUP] 3 [/SUP], Andreea Iren Serban[SUP] 4 [/SUP]
Affiliations
Abstract
oxidative stress is caused by an abundant generation of reactive oxygen species, associated to a diminished capacity of the endogenous systems of the organism to counteract them. Activation of pro-oxidative pathways and boosting of inflammatory cytokines are always encountered in viral infections, including SARS-CoV-2. So, the importance of counteracting cytokine storm in COVID-19 pathology is highly important, to hamper the immunogenic damage of the endothelium and alveolar membranes. Antioxidants prevent oxidative processes, by impeding radical species generation. It has been proved that vitamin intake lowers oxidative stress markers, alleviates cytokine storm and has a potential role in reducing disease severity, by lowering pro-inflammatory cytokines, hampering hyperinflammation and organ failure. For the approached compounds, direct antiviral roles are also discussed in this review, as these activities encompass secretion of antiviral peptides, modulation of angiotensin-converting enzyme 2 receptor expression and interaction with spike protein, inactivation of furin protease, or inhibition of pathogen replication by nucleic acid impairment induction. Vitamin administration results in beneficial effects. Nevertheless, timing, dosage and mutual influences of these micronutrients should be carefullly regarded.
Keywords: Antioxidants; Coronavirus; Cytokine storm; Immunomodulation; Viral infection; Vitamins.
. 2022 Feb 4;232:114175.
doi: 10.1016/j.ejmech.2022.114175. Online ahead of print.
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy
Aurelia Magdalena Pisoschi[SUP] 1 [/SUP], Aneta Pop[SUP] 2 [/SUP], Florin Iordache[SUP] 2 [/SUP], Loredana Stanca[SUP] 2 [/SUP], Ovidiu Ionut Geicu[SUP] 2 [/SUP], Liviu Bilteanu[SUP] 3 [/SUP], Andreea Iren Serban[SUP] 4 [/SUP]
Affiliations
- PMID: 35151223
- DOI: 10.1016/j.ejmech.2022.114175
Abstract
oxidative stress is caused by an abundant generation of reactive oxygen species, associated to a diminished capacity of the endogenous systems of the organism to counteract them. Activation of pro-oxidative pathways and boosting of inflammatory cytokines are always encountered in viral infections, including SARS-CoV-2. So, the importance of counteracting cytokine storm in COVID-19 pathology is highly important, to hamper the immunogenic damage of the endothelium and alveolar membranes. Antioxidants prevent oxidative processes, by impeding radical species generation. It has been proved that vitamin intake lowers oxidative stress markers, alleviates cytokine storm and has a potential role in reducing disease severity, by lowering pro-inflammatory cytokines, hampering hyperinflammation and organ failure. For the approached compounds, direct antiviral roles are also discussed in this review, as these activities encompass secretion of antiviral peptides, modulation of angiotensin-converting enzyme 2 receptor expression and interaction with spike protein, inactivation of furin protease, or inhibition of pathogen replication by nucleic acid impairment induction. Vitamin administration results in beneficial effects. Nevertheless, timing, dosage and mutual influences of these micronutrients should be carefullly regarded.
Keywords: Antioxidants; Coronavirus; Cytokine storm; Immunomodulation; Viral infection; Vitamins.