tetano
Editor, Senior Moderator
Eur J Immunol
. 2021 Mar 9.
doi: 10.1002/eji.202048984. Online ahead of print.
Insights into coronavirus immunity taught by the murine coronavirus
Sarah Grabherr[SUP] 1 [/SUP], Burkhard Ludewig[SUP] 1 2 [/SUP], Natalia Barbara Pikor[SUP] 1 [/SUP]
Affiliations
Abstract
Coronaviruses (CoVs) represent enveloped, single-stranded RNA viruses with the ability to infect a range of vertebrates causing mainly lung, central nervous system (CNS), enteric and hepatic disease. While the infection with human coronavirus is commonly associated with mild respiratory symptoms, the emergence of SARS-CoV, MERS-CoV and SARS-CoV-2 highlights the potential for coronaviruses to cause severe respiratory and systemic disease. The devastating global health burden caused by SARS-CoV-2 has spawned countless studies seeking clinical correlates of disease severity and host susceptibility factors, revealing a complex network of antiviral immune circuits. The mouse hepatitis virus (MHV) is, like SARS-CoV-2, a betacoronavirus and is endemic in wild mice. Laboratory MHV strains have been extensively studied to reveal coronavirus virulence factors and elucidate host mechanisms of antiviral immunity. These are reviewed here with the aim to identify translational insights for SARS-CoV-2 learned from murine coronaviruses. This article is protected by copyright. All rights reserved.
Keywords: Animal models; Host/pathogen interaction; Immune responses; Mouse Hepatitis Virus; SARS-CoV-2.
. 2021 Mar 9.
doi: 10.1002/eji.202048984. Online ahead of print.
Insights into coronavirus immunity taught by the murine coronavirus
Sarah Grabherr[SUP] 1 [/SUP], Burkhard Ludewig[SUP] 1 2 [/SUP], Natalia Barbara Pikor[SUP] 1 [/SUP]
Affiliations
- PMID: 33687066
- DOI: 10.1002/eji.202048984
Abstract
Coronaviruses (CoVs) represent enveloped, single-stranded RNA viruses with the ability to infect a range of vertebrates causing mainly lung, central nervous system (CNS), enteric and hepatic disease. While the infection with human coronavirus is commonly associated with mild respiratory symptoms, the emergence of SARS-CoV, MERS-CoV and SARS-CoV-2 highlights the potential for coronaviruses to cause severe respiratory and systemic disease. The devastating global health burden caused by SARS-CoV-2 has spawned countless studies seeking clinical correlates of disease severity and host susceptibility factors, revealing a complex network of antiviral immune circuits. The mouse hepatitis virus (MHV) is, like SARS-CoV-2, a betacoronavirus and is endemic in wild mice. Laboratory MHV strains have been extensively studied to reveal coronavirus virulence factors and elucidate host mechanisms of antiviral immunity. These are reviewed here with the aim to identify translational insights for SARS-CoV-2 learned from murine coronaviruses. This article is protected by copyright. All rights reserved.
Keywords: Animal models; Host/pathogen interaction; Immune responses; Mouse Hepatitis Virus; SARS-CoV-2.