tetano
Editor, Senior Moderator
Eur J Health Econ
. 2024 Mar 14.
doi: 10.1007/s10198-024-01683-1. Online ahead of print. Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands
Simon van der Pol[SUP] 1 2 [/SUP], Maarten J Postma[SUP] 3 4 5 [/SUP], Cornelis Boersma[SUP] 3 4 6 [/SUP]
Affiliations
Objectives: We perform a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) of baloxavir marboxil compared to current care in the Netherlands for patients at risk of influenza-related complications, including patients with comorbidities and the elderly.
Methods: In the CEA, a decision tree model was developed to assess the cost-effectiveness of baloxavir marboxil for a cohort of 52-year-olds from a societal perspective. A lifetime horizon was taken by incorporating the quality-adjusted life expectancy. The BIA included different epidemiological scenarios, estimating different plausible epidemiological scenarios for seasonal influenza considering the whole Dutch population with an increased risk of influenza complications.
Results: The base-case ICER was estimated to be €8,300 per QALY. At the willingness-to-pay threshold of €20,000 per QALY, the probability of being cost effective was 58%. The base-case expected budget impact was €5.7 million on average per year, ranging from €1.5 million to €10.5 million based on the severity of the influenza epidemic and vaccine effectiveness.
Conclusion: In the Netherlands, baloxavir is a cost-effective treatment option for seasonal influenza, with a base-case ICER of €8,300 per QALY for the population aged 60 years and over and patients at high risk of influenza-related complications. For a large part, this ICER is driven by the reduction of the illness duration of influenza and productivity gains in the working population.
Keywords: Antiviral; Baloxavir; Budget impact; Cost effectiveness; Seasonal influenza.
. 2024 Mar 14.
doi: 10.1007/s10198-024-01683-1. Online ahead of print. Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands
Simon van der Pol[SUP] 1 2 [/SUP], Maarten J Postma[SUP] 3 4 5 [/SUP], Cornelis Boersma[SUP] 3 4 6 [/SUP]
Affiliations
- PMID: 38483666
- DOI: 10.1007/s10198-024-01683-1
Objectives: We perform a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) of baloxavir marboxil compared to current care in the Netherlands for patients at risk of influenza-related complications, including patients with comorbidities and the elderly.
Methods: In the CEA, a decision tree model was developed to assess the cost-effectiveness of baloxavir marboxil for a cohort of 52-year-olds from a societal perspective. A lifetime horizon was taken by incorporating the quality-adjusted life expectancy. The BIA included different epidemiological scenarios, estimating different plausible epidemiological scenarios for seasonal influenza considering the whole Dutch population with an increased risk of influenza complications.
Results: The base-case ICER was estimated to be €8,300 per QALY. At the willingness-to-pay threshold of €20,000 per QALY, the probability of being cost effective was 58%. The base-case expected budget impact was €5.7 million on average per year, ranging from €1.5 million to €10.5 million based on the severity of the influenza epidemic and vaccine effectiveness.
Conclusion: In the Netherlands, baloxavir is a cost-effective treatment option for seasonal influenza, with a base-case ICER of €8,300 per QALY for the population aged 60 years and over and patients at high risk of influenza-related complications. For a large part, this ICER is driven by the reduction of the illness duration of influenza and productivity gains in the working population.
Keywords: Antiviral; Baloxavir; Budget impact; Cost effectiveness; Seasonal influenza.