tetano
Editor, Senior Moderator
Eur J Haematol
. 2020 Sep 16.
doi: 10.1111/ejh.13519. Online ahead of print.
SARS-CoV-2 infection among patients with haematological disorders: Severity and one-month outcome in 66 Danish patients in a nationwide cohort study
Andreas Glenth?j[SUP] 1 [/SUP], Lasse H Jakobsen[SUP] 2 3 [/SUP], Henrik Sengel?v[SUP] 4 [/SUP], Syed A Ahmad[SUP] 1 [/SUP], Kristian Qvist[SUP] 5 [/SUP], Annika Rewes[SUP] 6 [/SUP], Christian B Poulsen[SUP] 7 [/SUP], Ulrik M Overgaard[SUP] 4 [/SUP], Ingolf M?lle[SUP] 8 [/SUP], Marianne T Severinsen[SUP] 2 3 [/SUP], Casper N Strandholdt[SUP] 9 [/SUP], Jack Maibom[SUP] 7 [/SUP], Annette R Kodahl[SUP] 10 11 [/SUP], Jesper Ryg[SUP] 11 12 13 14 [/SUP], Pernille Ravn[SUP] 15 [/SUP], Isik S Johansen[SUP] 11 13 16 [/SUP], S?ren N Hels?[SUP] 2 [/SUP], S?ren Jensen-Fangel[SUP] 17 [/SUP], Jacek Kisielewicz[SUP] 18 [/SUP], Lothar Wiese[SUP] 19 [/SUP], Marie Helleberg[SUP] 20 [/SUP], Ole Kirk[SUP] 20 [/SUP], Michael R Clausen[SUP] 21 [/SUP], Henrik Frederiksen[SUP] 6 11 13 14 [/SUP]
Affiliations
Abstract
Objectives: Patients with haematological disorders may be particularly vulnerable to respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, however this is unknown.
Methods: We conducted a prospective, nationwide study including 66 patients in follow-up at Danish haematology departments with a malignant or non-malignant haematological disorder and with verified SARS-CoV-2 infection. Outcomes were intensive care unit (ICU) admission and one-month survival rate.
Results: Mean age was 66.7 years, 60.6% were males, 90.9% had comorbidity, and 13.6% had a BMI ≥30. The most frequent diagnoses were chronic lymphocytic leukaemia/lymphoma (47.0%), multiple myeloma (16.7%), and acute leukaemia/myelodysplastic syndrome (AL/MDS) (12.1%). Treatment for the haematological disease was ongoing in 59.1% of cases. Neutropenia was present in 6.5%, lymphopenia in 46.6%, and hypogammaglobulinaemia in 26?3%. The SARS-CoV-2 infection was mild in 50?0%, severe in 36?4%, and critical in 13.6%. After one month, 21.2% had been admitted to ICU, and 24.2% died. Mortality was highest in older patients, patients with severe/critical SARS-CoV-2 infection, high comorbidity score or high performance status score, purine analogue treatment, and with AL/MDS. Although older patients and patients with comorbidities had the highest mortality rates, mortality was considerable among all haematological patients.
Conclusion: Haematological patients with SARS-CoV-2 infection has a severe clinical.
Keywords: Immunology and infectious diseases.
. 2020 Sep 16.
doi: 10.1111/ejh.13519. Online ahead of print.
SARS-CoV-2 infection among patients with haematological disorders: Severity and one-month outcome in 66 Danish patients in a nationwide cohort study
Andreas Glenth?j[SUP] 1 [/SUP], Lasse H Jakobsen[SUP] 2 3 [/SUP], Henrik Sengel?v[SUP] 4 [/SUP], Syed A Ahmad[SUP] 1 [/SUP], Kristian Qvist[SUP] 5 [/SUP], Annika Rewes[SUP] 6 [/SUP], Christian B Poulsen[SUP] 7 [/SUP], Ulrik M Overgaard[SUP] 4 [/SUP], Ingolf M?lle[SUP] 8 [/SUP], Marianne T Severinsen[SUP] 2 3 [/SUP], Casper N Strandholdt[SUP] 9 [/SUP], Jack Maibom[SUP] 7 [/SUP], Annette R Kodahl[SUP] 10 11 [/SUP], Jesper Ryg[SUP] 11 12 13 14 [/SUP], Pernille Ravn[SUP] 15 [/SUP], Isik S Johansen[SUP] 11 13 16 [/SUP], S?ren N Hels?[SUP] 2 [/SUP], S?ren Jensen-Fangel[SUP] 17 [/SUP], Jacek Kisielewicz[SUP] 18 [/SUP], Lothar Wiese[SUP] 19 [/SUP], Marie Helleberg[SUP] 20 [/SUP], Ole Kirk[SUP] 20 [/SUP], Michael R Clausen[SUP] 21 [/SUP], Henrik Frederiksen[SUP] 6 11 13 14 [/SUP]
Affiliations
- PMID: 32939853
- DOI: 10.1111/ejh.13519
Abstract
Objectives: Patients with haematological disorders may be particularly vulnerable to respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, however this is unknown.
Methods: We conducted a prospective, nationwide study including 66 patients in follow-up at Danish haematology departments with a malignant or non-malignant haematological disorder and with verified SARS-CoV-2 infection. Outcomes were intensive care unit (ICU) admission and one-month survival rate.
Results: Mean age was 66.7 years, 60.6% were males, 90.9% had comorbidity, and 13.6% had a BMI ≥30. The most frequent diagnoses were chronic lymphocytic leukaemia/lymphoma (47.0%), multiple myeloma (16.7%), and acute leukaemia/myelodysplastic syndrome (AL/MDS) (12.1%). Treatment for the haematological disease was ongoing in 59.1% of cases. Neutropenia was present in 6.5%, lymphopenia in 46.6%, and hypogammaglobulinaemia in 26?3%. The SARS-CoV-2 infection was mild in 50?0%, severe in 36?4%, and critical in 13.6%. After one month, 21.2% had been admitted to ICU, and 24.2% died. Mortality was highest in older patients, patients with severe/critical SARS-CoV-2 infection, high comorbidity score or high performance status score, purine analogue treatment, and with AL/MDS. Although older patients and patients with comorbidities had the highest mortality rates, mortality was considerable among all haematological patients.
Conclusion: Haematological patients with SARS-CoV-2 infection has a severe clinical.
Keywords: Immunology and infectious diseases.