tetano
Editor, Senior Moderator
Eur J Haematol
. 2020 Aug 13.
doi: 10.1111/ejh.13509. Online ahead of print.
Characteristics of peripheral blood differential counts in hospitalized patients with COVID-19
Irene Pakos[SUP] 1 [/SUP], Kevin Bryan Lo[SUP] 1 [/SUP], Grace Salacup[SUP] 1 [/SUP], Jerald Pelayo[SUP] 1 [/SUP], Ruchika Bhargav[SUP] 1 [/SUP], Eric Peterson[SUP] 1 [/SUP], Fahad Gul[SUP] 1 [/SUP], Robert DeJoy 3rd[SUP] 1 [/SUP], Jeri Albano[SUP] 1 [/SUP], Gabriel Patarroyo-Aponte[SUP] 2 3 [/SUP], Janani Rangaswami[SUP] 1 3 [/SUP], Zurab Azmaiparashvili[SUP] 1 [/SUP]
Affiliations
Abstract
Background: A lot remains unknown about the features and laboratory findings that may predict worse outcomes in patients with Coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the difference in complete blood count parameters and differential counts in patients hospitalized with COVID-19 who survived compared to those who died.
Design: We performed a single center retrospective study including 242 patients with confirmed COVID-19. We described the characteristics of the complete blood count parameters in these patients. Mann Whitney-U test was used to compare hematologic parameters of patients who died and those who survived; multivariate logistic regression was used to look for associations with mortality.
Results: Patients with COVID-19 who died had significantly lower median absolute monocyte count (AMC) (0.4 vs 0.5, p=0.039) and median platelet count (169 vs 213, p=0.009) compared to those who survived. Patients who died had a significantly higher neutrophil to lymphocyte ratio (6.4 vs 4.5, p = 0.001). The NLR was positively associated with death (OR=1.038; 95% CI, 1.003 to 1.074, p=0.031) while AMC was inversely associated with death (OR=0.200; 95% CI, 0.052 to 0.761, p=0.018).
Conclusion: Among patients with COVID-19, a lower AMC and higher NLR are associated with higher mortality.
Keywords: COVID-19; lymphopenia; monocytes; novel coronavirus.
. 2020 Aug 13.
doi: 10.1111/ejh.13509. Online ahead of print.
Characteristics of peripheral blood differential counts in hospitalized patients with COVID-19
Irene Pakos[SUP] 1 [/SUP], Kevin Bryan Lo[SUP] 1 [/SUP], Grace Salacup[SUP] 1 [/SUP], Jerald Pelayo[SUP] 1 [/SUP], Ruchika Bhargav[SUP] 1 [/SUP], Eric Peterson[SUP] 1 [/SUP], Fahad Gul[SUP] 1 [/SUP], Robert DeJoy 3rd[SUP] 1 [/SUP], Jeri Albano[SUP] 1 [/SUP], Gabriel Patarroyo-Aponte[SUP] 2 3 [/SUP], Janani Rangaswami[SUP] 1 3 [/SUP], Zurab Azmaiparashvili[SUP] 1 [/SUP]
Affiliations
- PMID: 32794205
- DOI: 10.1111/ejh.13509
Abstract
Background: A lot remains unknown about the features and laboratory findings that may predict worse outcomes in patients with Coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the difference in complete blood count parameters and differential counts in patients hospitalized with COVID-19 who survived compared to those who died.
Design: We performed a single center retrospective study including 242 patients with confirmed COVID-19. We described the characteristics of the complete blood count parameters in these patients. Mann Whitney-U test was used to compare hematologic parameters of patients who died and those who survived; multivariate logistic regression was used to look for associations with mortality.
Results: Patients with COVID-19 who died had significantly lower median absolute monocyte count (AMC) (0.4 vs 0.5, p=0.039) and median platelet count (169 vs 213, p=0.009) compared to those who survived. Patients who died had a significantly higher neutrophil to lymphocyte ratio (6.4 vs 4.5, p = 0.001). The NLR was positively associated with death (OR=1.038; 95% CI, 1.003 to 1.074, p=0.031) while AMC was inversely associated with death (OR=0.200; 95% CI, 0.052 to 0.761, p=0.018).
Conclusion: Among patients with COVID-19, a lower AMC and higher NLR are associated with higher mortality.
Keywords: COVID-19; lymphopenia; monocytes; novel coronavirus.