tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis. 2020 Apr 24. doi: 10.1007/s10096-020-03899-4. [Epub ahead of print]
The genetic sequence, origin, and diagnosis of SARS-CoV-2.
Wang H[SUP]1[/SUP], Li X[SUP]1[/SUP], Li T[SUP]2,[/SUP][SUP]3[/SUP], Zhang S[SUP]1[/SUP], Wang L[SUP]1[/SUP], Wu X[SUP]1[/SUP], Liu J[SUP]1[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection.
KEYWORDS:
COVID-19; Diagnosis; Origin; SARS-CoV-2
PMID:32333222DOI:10.1007/s10096-020-03899-4
The genetic sequence, origin, and diagnosis of SARS-CoV-2.
Wang H[SUP]1[/SUP], Li X[SUP]1[/SUP], Li T[SUP]2,[/SUP][SUP]3[/SUP], Zhang S[SUP]1[/SUP], Wang L[SUP]1[/SUP], Wu X[SUP]1[/SUP], Liu J[SUP]1[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection.
KEYWORDS:
COVID-19; Diagnosis; Origin; SARS-CoV-2
PMID:32333222DOI:10.1007/s10096-020-03899-4