tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis
. 2026 Jan 29.
doi: 10.1007/s10096-026-05408-5. Online ahead of print.
Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial
Katrine Feldballe Bernholm[SUP] 1 2 [/SUP], Niklas Dyrby Johansen[SUP] 1 2 [/SUP], Caroline Espersen[SUP] 1 2 [/SUP], Daniel Modin[SUP] 1 2 [/SUP], Kira Janstrup Hyldekær[SUP] 1 2 [/SUP], Joshua Nealon[SUP] 3 [/SUP], Sandrine Samson[SUP] 3 [/SUP], Matthew M Loiacono[SUP] 4 [/SUP], Rebecca C Harris[SUP] 5 [/SUP], Carsten Schade Larsen[SUP] 6 [/SUP], Anne Marie Reimer Jensen[SUP] 1 2 [/SUP], Nino Emanuel Landler[SUP] 1 2 [/SUP], Signe Tellerup Nielsen[SUP] 7 [/SUP], Lene Russell[SUP] 7 [/SUP], Theis Skovsgaard Itenov[SUP] 8 [/SUP], Brian L Claggett[SUP] 9 [/SUP], Scott D Solomon[SUP] 9 [/SUP], Martin J Landray[SUP] 10 [/SUP], Gunnar H Gislason[SUP] 1 11 12 13 [/SUP], Lars Køber[SUP] 14 [/SUP], Pradeesh Sivapalan[SUP] 11 15 [/SUP], Jens Ulrik Stæhr Jensen[SUP] 11 15 [/SUP], Tor Biering-Sørensen[SUP] 16 17 18 [/SUP]
Affiliations
Purpose: The DANFLU-1 trial suggested lower incidence of hospitalizations for pneumonia and influenza, respiratory disease and all-cause mortality among older adults receiving high-dose (HD-IV) versus standard-dose (SD-IV) influenza vaccine. This study assessed the relative effectiveness of HD-IV versus SD-IV according to comorbidity in elderly individuals.
Methods: This was a post-hoc analysis of the DANFLU-1 randomized controlled feasibility trial of HD-IV versus SD-IV conducted during the 2021-2022 influenza season in adults aged 65-79 years. Outcomes assessed included influenza-related, respiratory, and cardiovascular hospitalizations, and mortality. We tested for effect modification by level of the Charlson Comorbidity Index (CCI) using ICD-10 codes up to 10 years prior to randomization.
Results: Of the 12,477 randomly assigned participants (mean age 71.7 ± 3.9 years, 47.1% female), 8,020 (64.3%) had CCI = 0, 3,560 (28.5%) had CCI = 1-2 and 893 (7.2%) had CCI ≥ 3. When comparing HD-IV with SD-IV, hazard ratios of hospitalizations for pneumonia and influenza were similar across CCI groups (HR [95%CI]: 0.15 [0.03-0.68] for CCI = 0, 0.36 [0.11-1.15] for CCI = 1-2, 1.00 [0.25-4.00] for CCI ≥ 3). Comparable patterns were found for hospitalizations for respiratory disease (0.46 [0.17-1.20] for CCI = 0, 0.67 [0.32-1.39] for CCI = 1-2, 0.66 [0.24-1.87] for CCI ≥ 3) and all-cause mortality (0.28 [0.09-0.86] for CCI = 0, 0.70 [0.30-1.63] for CCI = 1-2, 0.57 [0.24-1.36] for CCI ≥ 3). There was no statistical evidence of effect modification by CCI for any outcome.
Conclusions: The lower incidences of clinical outcomes for HD-IV compared to SD-IV were not significantly modified by CCI. The potential benefit of HD-IV versus SD-IV may therefore be applicable regardless of comorbidity burden. Further research is required to confirm these findings.
Keywords: Charlson Comorbidity Index; Comorbidity; Hospitalizations; Influenza vaccine; Mortality; Pragmatic randomized controlled trial.
. 2026 Jan 29.
doi: 10.1007/s10096-026-05408-5. Online ahead of print.
Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial
Katrine Feldballe Bernholm[SUP] 1 2 [/SUP], Niklas Dyrby Johansen[SUP] 1 2 [/SUP], Caroline Espersen[SUP] 1 2 [/SUP], Daniel Modin[SUP] 1 2 [/SUP], Kira Janstrup Hyldekær[SUP] 1 2 [/SUP], Joshua Nealon[SUP] 3 [/SUP], Sandrine Samson[SUP] 3 [/SUP], Matthew M Loiacono[SUP] 4 [/SUP], Rebecca C Harris[SUP] 5 [/SUP], Carsten Schade Larsen[SUP] 6 [/SUP], Anne Marie Reimer Jensen[SUP] 1 2 [/SUP], Nino Emanuel Landler[SUP] 1 2 [/SUP], Signe Tellerup Nielsen[SUP] 7 [/SUP], Lene Russell[SUP] 7 [/SUP], Theis Skovsgaard Itenov[SUP] 8 [/SUP], Brian L Claggett[SUP] 9 [/SUP], Scott D Solomon[SUP] 9 [/SUP], Martin J Landray[SUP] 10 [/SUP], Gunnar H Gislason[SUP] 1 11 12 13 [/SUP], Lars Køber[SUP] 14 [/SUP], Pradeesh Sivapalan[SUP] 11 15 [/SUP], Jens Ulrik Stæhr Jensen[SUP] 11 15 [/SUP], Tor Biering-Sørensen[SUP] 16 17 18 [/SUP]
Affiliations
- PMID: 41609947
- DOI: 10.1007/s10096-026-05408-5
Purpose: The DANFLU-1 trial suggested lower incidence of hospitalizations for pneumonia and influenza, respiratory disease and all-cause mortality among older adults receiving high-dose (HD-IV) versus standard-dose (SD-IV) influenza vaccine. This study assessed the relative effectiveness of HD-IV versus SD-IV according to comorbidity in elderly individuals.
Methods: This was a post-hoc analysis of the DANFLU-1 randomized controlled feasibility trial of HD-IV versus SD-IV conducted during the 2021-2022 influenza season in adults aged 65-79 years. Outcomes assessed included influenza-related, respiratory, and cardiovascular hospitalizations, and mortality. We tested for effect modification by level of the Charlson Comorbidity Index (CCI) using ICD-10 codes up to 10 years prior to randomization.
Results: Of the 12,477 randomly assigned participants (mean age 71.7 ± 3.9 years, 47.1% female), 8,020 (64.3%) had CCI = 0, 3,560 (28.5%) had CCI = 1-2 and 893 (7.2%) had CCI ≥ 3. When comparing HD-IV with SD-IV, hazard ratios of hospitalizations for pneumonia and influenza were similar across CCI groups (HR [95%CI]: 0.15 [0.03-0.68] for CCI = 0, 0.36 [0.11-1.15] for CCI = 1-2, 1.00 [0.25-4.00] for CCI ≥ 3). Comparable patterns were found for hospitalizations for respiratory disease (0.46 [0.17-1.20] for CCI = 0, 0.67 [0.32-1.39] for CCI = 1-2, 0.66 [0.24-1.87] for CCI ≥ 3) and all-cause mortality (0.28 [0.09-0.86] for CCI = 0, 0.70 [0.30-1.63] for CCI = 1-2, 0.57 [0.24-1.36] for CCI ≥ 3). There was no statistical evidence of effect modification by CCI for any outcome.
Conclusions: The lower incidences of clinical outcomes for HD-IV compared to SD-IV were not significantly modified by CCI. The potential benefit of HD-IV versus SD-IV may therefore be applicable regardless of comorbidity burden. Further research is required to confirm these findings.
Keywords: Charlson Comorbidity Index; Comorbidity; Hospitalizations; Influenza vaccine; Mortality; Pragmatic randomized controlled trial.