tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis
. 2022 Jan 24.
doi: 10.1007/s10096-022-04401-y. Online ahead of print.
Protocatechuic acid protects mice from influenza A virus infection
Qian Wang[SUP] 1 [/SUP], Xiaojuan Ren[SUP] 2 [/SUP], Jinhua Wu[SUP] 2 [/SUP], Hongrong Li[SUP] 2 [/SUP], Liu Yang[SUP] 2 [/SUP], Yan Zhang[SUP] 2 [/SUP], Xin Wang[SUP] 2 [/SUP], Zhicun Li[SUP] 2 [/SUP]
Affiliations
Abstract
Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechuic acid (PCA) is a biological agent with multiple functions. In present study, we explored the effects of PCA on H1N1 infection. Mice infected with mouse adapted influenza strain A/Font Monmouth were administrated with PCA. The body weight change, mortality, lung index, viral titer, immune cell infiltration, and cytokine production in the lung were monitored. The activation of toll-like receptor 4 (TLR4) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway was investigated. PCA treatment prevented H1N1 infection-induced mice body weight loss and death. PCA reduced the lung index, viral titer, infiltration of immune cells, and cytokine level in the lung, as well as suppressed H1N1-induced TLR4/NF-κB activation. PCA protects mice against H1N1 infection and could be a potential therapeutic agent to treat influenza.
Keywords: Influenza; Mice; Protection; Protocatechuic acid.
. 2022 Jan 24.
doi: 10.1007/s10096-022-04401-y. Online ahead of print.
Protocatechuic acid protects mice from influenza A virus infection
Qian Wang[SUP] 1 [/SUP], Xiaojuan Ren[SUP] 2 [/SUP], Jinhua Wu[SUP] 2 [/SUP], Hongrong Li[SUP] 2 [/SUP], Liu Yang[SUP] 2 [/SUP], Yan Zhang[SUP] 2 [/SUP], Xin Wang[SUP] 2 [/SUP], Zhicun Li[SUP] 2 [/SUP]
Affiliations
- PMID: 35067799
- DOI: 10.1007/s10096-022-04401-y
Abstract
Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechuic acid (PCA) is a biological agent with multiple functions. In present study, we explored the effects of PCA on H1N1 infection. Mice infected with mouse adapted influenza strain A/Font Monmouth were administrated with PCA. The body weight change, mortality, lung index, viral titer, immune cell infiltration, and cytokine production in the lung were monitored. The activation of toll-like receptor 4 (TLR4) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway was investigated. PCA treatment prevented H1N1 infection-induced mice body weight loss and death. PCA reduced the lung index, viral titer, infiltration of immune cells, and cytokine level in the lung, as well as suppressed H1N1-induced TLR4/NF-κB activation. PCA protects mice against H1N1 infection and could be a potential therapeutic agent to treat influenza.
Keywords: Influenza; Mice; Protection; Protocatechuic acid.