tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis
. 2021 Oct 9.
doi: 10.1007/s10096-021-04360-w. Online ahead of print.
Clinical and immunological characteristics in COVID-19 convalescent patients
Zhiying Su[SUP] #[/SUP][SUP] 1 [/SUP], Wenjia Hu[SUP] #[/SUP][SUP] 1 [/SUP], Qianyun Liu[SUP] #[/SUP][SUP] 2 [/SUP], Yongxi Zhang[SUP] 1 [/SUP], Tielong Chen[SUP] 1 [/SUP], Yingying Zhou[SUP] 1 [/SUP], Zhen Zhang[SUP] 2 [/SUP], Yu Chen[SUP] #[/SUP][SUP] 2 [/SUP], Rongrong Yang[SUP] #[/SUP][SUP] 1 [/SUP], Yong Xiong[SUP] #[/SUP][SUP] 3 [/SUP], Xinghuan Wang[SUP] #[/SUP][SUP] 4 [/SUP]
Affiliations
Abstract
The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4[SUP]+[/SUP] T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.
Keywords: Humoral immunity; Neutralizing antibodies; SARS-CoV-2; Virus-specific T cells.
. 2021 Oct 9.
doi: 10.1007/s10096-021-04360-w. Online ahead of print.
Clinical and immunological characteristics in COVID-19 convalescent patients
Zhiying Su[SUP] #[/SUP][SUP] 1 [/SUP], Wenjia Hu[SUP] #[/SUP][SUP] 1 [/SUP], Qianyun Liu[SUP] #[/SUP][SUP] 2 [/SUP], Yongxi Zhang[SUP] 1 [/SUP], Tielong Chen[SUP] 1 [/SUP], Yingying Zhou[SUP] 1 [/SUP], Zhen Zhang[SUP] 2 [/SUP], Yu Chen[SUP] #[/SUP][SUP] 2 [/SUP], Rongrong Yang[SUP] #[/SUP][SUP] 1 [/SUP], Yong Xiong[SUP] #[/SUP][SUP] 3 [/SUP], Xinghuan Wang[SUP] #[/SUP][SUP] 4 [/SUP]
Affiliations
- PMID: 34625887
- DOI: 10.1007/s10096-021-04360-w
Abstract
The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4[SUP]+[/SUP] T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.
Keywords: Humoral immunity; Neutralizing antibodies; SARS-CoV-2; Virus-specific T cells.