tetano
Editor, Senior Moderator
Eur J Clin Invest
. 2022 Mar 28;e13781.
doi: 10.1111/eci.13781. Online ahead of print.
The prognostic role of interatrial block among COVID-19 patients hospitalized in medicine wards
Vincenzo Russo[SUP] 1 [/SUP], Stefano Albani[SUP] 2 [/SUP], Alfredo Caturano[SUP] 3 [/SUP], Sara Hana Weisz[SUP] 4 [/SUP], Valentina Parisi[SUP] 5 [/SUP], Maddalena Conte[SUP] 5 [/SUP], Lorenzo Zuccaro[SUP] 2 [/SUP], Antonello D'Andrea[SUP] 6 [/SUP], Ahmed Al-Turky[SUP] 7 [/SUP], Michal Marchel[SUP] 8 [/SUP], Marco Marano[SUP] 9 [/SUP], Ferdinando Carlo Sasso[SUP] 3 [/SUP], Emilio Attena[SUP] 8 [/SUP]
Affiliations
Abstract
Introduction: Some abnormal electrocardiographic findings were independently associated with increased mortality in patients admitted for COVID-19; however, no studies have focused on the prognosis impact of interatrial block (IAB) in this clinical setting. The aim of our study was to assess the prevalence and clinical implications of IAB, both partial and advanced, in hospitalized COVID-19 patients.
Materials: We retrospectively evaluated 300 consecutive COVID-19 patients (63.22± 15.16 years; 70% males) admitted to eight Italian Hospitals from February 2020 to April 2020 who underwent twelve leads electrocardiographic recording at admission. The study population has been dichotomized into two groups according to the evidence of IAB at admission, both partial and advanced. The differences in terms of ARDS in need of intubation, in-hospital mortality and thromboembolic events (a composite of myocardial infarction, stroke and transient ischemic attack) have been evaluated.
Results: The presence of IAB was noticed in 64 patients (21%). At adjusted logistic regression model, the partial interatrial block was found to be an independent predictor of ARDS in need of intubation (HR: 1.92; P:0.04) and in-hospital mortality (HR: 2.65; P: 0.02); moreover, the advanced interatrial block was an independent predictor of thrombotic events (HR: 7.14; P< 0.001).
Conclusions: Among COVID-19 patients hospitalized in medicine wards, the presence of interatrial block is more frequent than in the general population and it might be useful as an early predictor for increased risk of incident thrombotic events, ARDS in need of intubation and in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; atrial fibrillation; interatrial block, acute respiratory distress syndrome.; mortality; novel coronavirus; outcome.
. 2022 Mar 28;e13781.
doi: 10.1111/eci.13781. Online ahead of print.
The prognostic role of interatrial block among COVID-19 patients hospitalized in medicine wards
Vincenzo Russo[SUP] 1 [/SUP], Stefano Albani[SUP] 2 [/SUP], Alfredo Caturano[SUP] 3 [/SUP], Sara Hana Weisz[SUP] 4 [/SUP], Valentina Parisi[SUP] 5 [/SUP], Maddalena Conte[SUP] 5 [/SUP], Lorenzo Zuccaro[SUP] 2 [/SUP], Antonello D'Andrea[SUP] 6 [/SUP], Ahmed Al-Turky[SUP] 7 [/SUP], Michal Marchel[SUP] 8 [/SUP], Marco Marano[SUP] 9 [/SUP], Ferdinando Carlo Sasso[SUP] 3 [/SUP], Emilio Attena[SUP] 8 [/SUP]
Affiliations
- PMID: 35342933
- DOI: 10.1111/eci.13781
Abstract
Introduction: Some abnormal electrocardiographic findings were independently associated with increased mortality in patients admitted for COVID-19; however, no studies have focused on the prognosis impact of interatrial block (IAB) in this clinical setting. The aim of our study was to assess the prevalence and clinical implications of IAB, both partial and advanced, in hospitalized COVID-19 patients.
Materials: We retrospectively evaluated 300 consecutive COVID-19 patients (63.22± 15.16 years; 70% males) admitted to eight Italian Hospitals from February 2020 to April 2020 who underwent twelve leads electrocardiographic recording at admission. The study population has been dichotomized into two groups according to the evidence of IAB at admission, both partial and advanced. The differences in terms of ARDS in need of intubation, in-hospital mortality and thromboembolic events (a composite of myocardial infarction, stroke and transient ischemic attack) have been evaluated.
Results: The presence of IAB was noticed in 64 patients (21%). At adjusted logistic regression model, the partial interatrial block was found to be an independent predictor of ARDS in need of intubation (HR: 1.92; P:0.04) and in-hospital mortality (HR: 2.65; P: 0.02); moreover, the advanced interatrial block was an independent predictor of thrombotic events (HR: 7.14; P< 0.001).
Conclusions: Among COVID-19 patients hospitalized in medicine wards, the presence of interatrial block is more frequent than in the general population and it might be useful as an early predictor for increased risk of incident thrombotic events, ARDS in need of intubation and in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; atrial fibrillation; interatrial block, acute respiratory distress syndrome.; mortality; novel coronavirus; outcome.