tetano
Editor, Senior Moderator
Eur Heart J Case Rep
. 2020 May 8;4(FI1):1-6.
doi: 10.1093/ehjcr/ytaa132. eCollection 2020 Oct.
Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series
Graham Peigh[SUP] 1 [/SUP], Marysa V Leya[SUP] 1 [/SUP], Jayson R Baman[SUP] 1 [/SUP], Eric P Cantey[SUP] 1 [/SUP], Bradley P Knight[SUP] 1 [/SUP], James D Flaherty[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Novel coronavirus-19 disease (COVID-19) is associated with significant cardiovascular morbidity and mortality. To date, there have not been reports of sinus node dysfunction (SND) associated with COVID-19. This case series describes clinical characteristics, potential mechanisms, and short-term outcomes of COVID-19 patients who experience de novo SND.
Case summary: We present two cases of new-onset SND in patients recently diagnosed with COVID-19. Patient 1 is a 70-year-old female with no major past medical history who was intubated for acute hypoxic respiratory failure secondary to COVID-19 pneumonia and developed new-onset sinus bradycardia without a compensatory increase in heart rate in response to relative hypotension. Patient 2 is an 81-year-old male with a past medical history of an ascending aortic aneurysm, hypertension, and obstructive sleep apnoea who required intubation for COVID-19-induced acute hypoxic respiratory failure and exhibited new-onset sinus bradycardia followed by numerous episodes of haemodynamically significant accelerated idioventricular rhythm. Two weeks following the onset of SND, both patients remain in sinus bradycardia.
Discussion: COVID-19-associated SND has not previously been described. The potential mechanisms for SND in patients with COVID-19 include myocardial inflammation or direct viral infiltration. Patients diagnosed with COVID-19 should be monitored closely for the development of bradyarrhythmia and haemodynamic instability.
Keywords: Bradycardia; COVID-19; Case series; SARS-CoV-2; Sinus node dysfunction.
. 2020 May 8;4(FI1):1-6.
doi: 10.1093/ehjcr/ytaa132. eCollection 2020 Oct.
Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series
Graham Peigh[SUP] 1 [/SUP], Marysa V Leya[SUP] 1 [/SUP], Jayson R Baman[SUP] 1 [/SUP], Eric P Cantey[SUP] 1 [/SUP], Bradley P Knight[SUP] 1 [/SUP], James D Flaherty[SUP] 1 [/SUP]
Affiliations
- PMID: 33089039
- PMCID: PMC7239209
- DOI: 10.1093/ehjcr/ytaa132
Abstract
Background: Novel coronavirus-19 disease (COVID-19) is associated with significant cardiovascular morbidity and mortality. To date, there have not been reports of sinus node dysfunction (SND) associated with COVID-19. This case series describes clinical characteristics, potential mechanisms, and short-term outcomes of COVID-19 patients who experience de novo SND.
Case summary: We present two cases of new-onset SND in patients recently diagnosed with COVID-19. Patient 1 is a 70-year-old female with no major past medical history who was intubated for acute hypoxic respiratory failure secondary to COVID-19 pneumonia and developed new-onset sinus bradycardia without a compensatory increase in heart rate in response to relative hypotension. Patient 2 is an 81-year-old male with a past medical history of an ascending aortic aneurysm, hypertension, and obstructive sleep apnoea who required intubation for COVID-19-induced acute hypoxic respiratory failure and exhibited new-onset sinus bradycardia followed by numerous episodes of haemodynamically significant accelerated idioventricular rhythm. Two weeks following the onset of SND, both patients remain in sinus bradycardia.
Discussion: COVID-19-associated SND has not previously been described. The potential mechanisms for SND in patients with COVID-19 include myocardial inflammation or direct viral infiltration. Patients diagnosed with COVID-19 should be monitored closely for the development of bradyarrhythmia and haemodynamic instability.
Keywords: Bradycardia; COVID-19; Case series; SARS-CoV-2; Sinus node dysfunction.