tetano
Editor, Senior Moderator
Eur Heart J Acute Cardiovasc Care
. 2020 Nov 21;2048872620974605.
doi: 10.1177/2048872620974605. Online ahead of print.
Cardiac complications in patients hospitalised with COVID-19
Marijke Linschoten[SUP] 1 [/SUP], Sanne Peters[SUP] 2 3 4 [/SUP], Maarten van Smeden[SUP] 2 [/SUP], Lucia S Jewbali[SUP] 5 6 [/SUP], Jeroen Schaap[SUP] 7 [/SUP], Hans-Marc Siebelink[SUP] 8 [/SUP], Peter C Smits[SUP] 9 [/SUP], Robert G Tieleman[SUP] 10 [/SUP], Pim van der Harst[SUP] 1 [/SUP], Wiek H van Gilst[SUP] 11 [/SUP], Folkert W Asselbergs[SUP] 1 12 13 [/SUP], CAPACITY-COVID collaborative consortium
Affiliations
Abstract
Aims: To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19).
Methods and results: CAPACITY-COVID is an international patient registry established to determine the role of cardiovascular disease in the COVID-19 pandemic. In this registry, data generated during routine clinical practice are collected in a standardised manner for patients with a (highly suspected) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requiring hospitalisation. For the current analysis, consecutive patients with laboratory confirmed COVID-19 registered between 28 March and 3 July 2020 were included. Patients were followed for the occurrence of cardiac complications and pulmonary embolism from admission to discharge. In total, 3011 patients were included, of which 1890 (62.8%) were men. The median age was 67 years (interquartile range 56-76); 937 (31.0%) patients had a history of cardiac disease, with pre-existent coronary artery disease being most common (n=463, 15.4%). During hospitalisation, 595 (19.8%) patients died, including 16 patients (2.7%) with cardiac causes. Cardiac complications were diagnosed in 349 (11.6%) patients, with atrial fibrillation (n=142, 4.7%) being most common. The incidence of other cardiac complications was 1.8% for heart failure (n=55), 0.5% for acute coronary syndrome (n=15), 0.5% for ventricular arrhythmia (n=14), 0.1% for bacterial endocarditis (n=4) and myocarditis (n=3), respectively, and 0.03% for pericarditis (n=1). Pulmonary embolism was diagnosed in 198 (6.6%) patients.
Conclusion: This large study among 3011 hospitalised patients with COVID-19 shows that the incidence of cardiac complications during hospital admission is low, despite a frequent history of cardiovascular disease. Long-term cardiac outcomes and the role of pre-existing cardiovascular disease in COVID-19 outcome warrants further investigation.
Keywords: COVID-19/coronavirus; cardiac complications; cohorts; patient registry; pulmonary embolism.
. 2020 Nov 21;2048872620974605.
doi: 10.1177/2048872620974605. Online ahead of print.
Cardiac complications in patients hospitalised with COVID-19
Marijke Linschoten[SUP] 1 [/SUP], Sanne Peters[SUP] 2 3 4 [/SUP], Maarten van Smeden[SUP] 2 [/SUP], Lucia S Jewbali[SUP] 5 6 [/SUP], Jeroen Schaap[SUP] 7 [/SUP], Hans-Marc Siebelink[SUP] 8 [/SUP], Peter C Smits[SUP] 9 [/SUP], Robert G Tieleman[SUP] 10 [/SUP], Pim van der Harst[SUP] 1 [/SUP], Wiek H van Gilst[SUP] 11 [/SUP], Folkert W Asselbergs[SUP] 1 12 13 [/SUP], CAPACITY-COVID collaborative consortium
Affiliations
- PMID: 33222494
- DOI: 10.1177/2048872620974605
Abstract
Aims: To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19).
Methods and results: CAPACITY-COVID is an international patient registry established to determine the role of cardiovascular disease in the COVID-19 pandemic. In this registry, data generated during routine clinical practice are collected in a standardised manner for patients with a (highly suspected) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requiring hospitalisation. For the current analysis, consecutive patients with laboratory confirmed COVID-19 registered between 28 March and 3 July 2020 were included. Patients were followed for the occurrence of cardiac complications and pulmonary embolism from admission to discharge. In total, 3011 patients were included, of which 1890 (62.8%) were men. The median age was 67 years (interquartile range 56-76); 937 (31.0%) patients had a history of cardiac disease, with pre-existent coronary artery disease being most common (n=463, 15.4%). During hospitalisation, 595 (19.8%) patients died, including 16 patients (2.7%) with cardiac causes. Cardiac complications were diagnosed in 349 (11.6%) patients, with atrial fibrillation (n=142, 4.7%) being most common. The incidence of other cardiac complications was 1.8% for heart failure (n=55), 0.5% for acute coronary syndrome (n=15), 0.5% for ventricular arrhythmia (n=14), 0.1% for bacterial endocarditis (n=4) and myocarditis (n=3), respectively, and 0.03% for pericarditis (n=1). Pulmonary embolism was diagnosed in 198 (6.6%) patients.
Conclusion: This large study among 3011 hospitalised patients with COVID-19 shows that the incidence of cardiac complications during hospital admission is low, despite a frequent history of cardiovascular disease. Long-term cardiac outcomes and the role of pre-existing cardiovascular disease in COVID-19 outcome warrants further investigation.
Keywords: COVID-19/coronavirus; cardiac complications; cohorts; patient registry; pulmonary embolism.