tetano
Editor, Senior Moderator
Eur Cardiol
. 2020 Jun 23;15:e52.
doi: 10.15420/ecr.2020.22. eCollection 2020 Feb.
Myocardial and Microvascular Injury Due to Coronavirus Disease 2019
Rocco A Montone[SUP] 1 [/SUP], Giulia Iannaccone[SUP] 2 [/SUP], Maria Chiara Meucci[SUP] 2 [/SUP], Filippo Gurgoglione[SUP] 2 [/SUP], Giampaolo Niccoli[SUP] 1 2 [/SUP]
AffiliationsExpand
Abstract
Over the past few months, health systems worldwide have been put to the test with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though the leading clinical manifestations of the SARS-CoV-2 infection involve the respiratory tract, there is a non-negligible risk of systemic involvement leading to the onset of multi-organ failure with fatal consequences. Since the onset of COVID-19, patients with underlying cardiovascular disease have been at increased risk of poor clinical outcomes with higher death rates. Moreover, the occurrence of new-onset cardiac complications is not uncommon among patients hospitalised for COVID-19. Of importance, a significant portion of COVID-19 patients present with myocardial injury. Herein, the authors discuss the mechanisms leading to myocardial and microvascular injury in SARS-CoV-2 infection and their clinical implications.
Keywords: COVID-19; MI; microvascular dysfunction; microvascular injury; myocardial injury.
. 2020 Jun 23;15:e52.
doi: 10.15420/ecr.2020.22. eCollection 2020 Feb.
Myocardial and Microvascular Injury Due to Coronavirus Disease 2019
Rocco A Montone[SUP] 1 [/SUP], Giulia Iannaccone[SUP] 2 [/SUP], Maria Chiara Meucci[SUP] 2 [/SUP], Filippo Gurgoglione[SUP] 2 [/SUP], Giampaolo Niccoli[SUP] 1 2 [/SUP]
AffiliationsExpand
- PMID: 32617121
- PMCID: PMC7325215
- DOI: 10.15420/ecr.2020.22
Abstract
Over the past few months, health systems worldwide have been put to the test with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though the leading clinical manifestations of the SARS-CoV-2 infection involve the respiratory tract, there is a non-negligible risk of systemic involvement leading to the onset of multi-organ failure with fatal consequences. Since the onset of COVID-19, patients with underlying cardiovascular disease have been at increased risk of poor clinical outcomes with higher death rates. Moreover, the occurrence of new-onset cardiac complications is not uncommon among patients hospitalised for COVID-19. Of importance, a significant portion of COVID-19 patients present with myocardial injury. Herein, the authors discuss the mechanisms leading to myocardial and microvascular injury in SARS-CoV-2 infection and their clinical implications.
Keywords: COVID-19; MI; microvascular dysfunction; microvascular injury; myocardial injury.