tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2012 May 30. [Epub ahead of print]
Etiology and Seasonality of Viral Respiratory Infections in Rural Honduran Children.
Schlaudecker EP, Heck JP, Macintyre ET, Martinez R, Dodd CN, McNeal MM, Staat MA, Heck JE, Steinhoff MC.
Source
1Division of Infectious Diseases, Global Health Center, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA 2Harvard University, Cambridge, MA, USA 3Weill Cornell Medical College of Cornell University, New York, NY, USA 4Shoulder to Shoulder, Santa Lucia, Intibuc?, Honduras 5Global Health Center, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA 6Department of Family Medicine, University of North Carolina, Asheville, NC, USA.
Abstract
BACKGROUND:
Limited data are available in Honduras describing the etiology and seasonality of respiratory infections, especially in rural outpatient settings. Better data may lead to improved therapeutic and preventative strategies. The goal of our study was to determine the viral etiology and seasonality of acute respiratory infections in a rural Honduran population of children.
METHODS:
Prospective clinic surveillance was conducted to identify children <5 years of age presenting with respiratory symptoms <5 days duration. We obtained data on age, sex, medical history, breastfeeding history, symptoms, risk factors, household setting, temperature, respiratory rate, and chest exam findings. To assess the association between specific viruses and weather, regional meteorological data were collected. Nasopharyngeal samples were tested for 16 respiratory viruses using a multiplex PCR panel.
RESULTS:
From February 2010 through June 2011, 345 children <5 years of age were enrolled; 17%, 23%, 30%, and 31% were <6, 6-11, 12-23, and 24-60 months old, respectively. Including all clinics in the region, 44.5% of patients <5 years of age with documented respiratory diagnoses were enrolled. At least one virus was identified in 75.4% children, of which 7.5% were co-infections; 13.3% were positive for parainfluenza, 11.9% for influenza, 8.1% for human metapneumovirus (hMPV), and 7.5% for respiratory syncytial virus (RSV). Rainfall correlated with parainfluenza (p≤0.0001), influenza (p≤0.0001), hMPV (p= 0.0182), and RSV (p≤0.0001).
CONCLUSIONS:
These results suggest that the spectrum of viruses in ill rural Honduran children is similar to that in North and Central America, though the seasonality is typical of some tropical regions.
PMID:
22653487
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22653487
Etiology and Seasonality of Viral Respiratory Infections in Rural Honduran Children.
Schlaudecker EP, Heck JP, Macintyre ET, Martinez R, Dodd CN, McNeal MM, Staat MA, Heck JE, Steinhoff MC.
Source
1Division of Infectious Diseases, Global Health Center, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA 2Harvard University, Cambridge, MA, USA 3Weill Cornell Medical College of Cornell University, New York, NY, USA 4Shoulder to Shoulder, Santa Lucia, Intibuc?, Honduras 5Global Health Center, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA 6Department of Family Medicine, University of North Carolina, Asheville, NC, USA.
Abstract
BACKGROUND:
Limited data are available in Honduras describing the etiology and seasonality of respiratory infections, especially in rural outpatient settings. Better data may lead to improved therapeutic and preventative strategies. The goal of our study was to determine the viral etiology and seasonality of acute respiratory infections in a rural Honduran population of children.
METHODS:
Prospective clinic surveillance was conducted to identify children <5 years of age presenting with respiratory symptoms <5 days duration. We obtained data on age, sex, medical history, breastfeeding history, symptoms, risk factors, household setting, temperature, respiratory rate, and chest exam findings. To assess the association between specific viruses and weather, regional meteorological data were collected. Nasopharyngeal samples were tested for 16 respiratory viruses using a multiplex PCR panel.
RESULTS:
From February 2010 through June 2011, 345 children <5 years of age were enrolled; 17%, 23%, 30%, and 31% were <6, 6-11, 12-23, and 24-60 months old, respectively. Including all clinics in the region, 44.5% of patients <5 years of age with documented respiratory diagnoses were enrolled. At least one virus was identified in 75.4% children, of which 7.5% were co-infections; 13.3% were positive for parainfluenza, 11.9% for influenza, 8.1% for human metapneumovirus (hMPV), and 7.5% for respiratory syncytial virus (RSV). Rainfall correlated with parainfluenza (p≤0.0001), influenza (p≤0.0001), hMPV (p= 0.0182), and RSV (p≤0.0001).
CONCLUSIONS:
These results suggest that the spectrum of viruses in ill rural Honduran children is similar to that in North and Central America, though the seasonality is typical of some tropical regions.
PMID:
22653487
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22653487