tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2015 May 16. doi: 10.1111/irv.12325. [Epub ahead of print]
[h=1]Estimating the hospitalization burden associated with influenza and respiratory syncytial virus in New York City, 2003-2011.[/h] Goldstein E[SUP]1[/SUP], Greene SK[SUP]2[/SUP], Olson DR[SUP]3[/SUP], Hanage WP[SUP]1[/SUP], Lipsitch M[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Hospitalization burden associated with influenza and respiratory syncytial virus (RSV) is uncertain due to ambiguity in the inference methodologies employed for its estimation.
[h=4]OBJECTIVES:[/h] Utilization of a new method to quantify the above burden.
[h=4]METHODS:[/h] Weekly hospitalization rates for several principal diagnoses from 2003-2011 in New York City by age group were regressed linearly against incidence proxies for the major influenza subtypes and RSV adjusting for temporal trends and seasonal baselines.
[h=4]RESULTS:[/h] Average annual rates of influenza-associated respiratory hospitalizations per 100,000 were estimated to be 129(95% CI (79,179)) for age <1, 36.3(21.6,51.4) for ages 1-4, 10.6(7.5,13.7) for ages 5-17, 25.6(21.3,29.8) for ages 18-49, 65.5(54.0,76.9) for ages 50-64, 125(105,147) for ages 65-74, and 288(244,331) for ages ≥75. Additionally, influenza had a significant contribution to hospitalization rates with a principal diagnosis of septicemia for ages 5-17 (0.76(0.1,1.4)), 18-49 (1.02(0.3,1.7)), 50-64 (4.0(1.7,6.3)), 65-74 (8.8(2.2,15.6)) and ≥75 (38.7(25.7,52.9)). RSV had a significant contribution to the rates of respiratory hospitalizations for age <1 (1900(1740,2060)), ages 1-4 (117(70,167)) and ≥75 (175(44,312)) (including chronic lower respiratory disease, 90(43,140.)) as well as pneumonia & influenza hospitalizations for ages 18-49 (6.2(1.1,11.3)) and circulatory hospitalizations for ages 1-4 (13.2(2.6,23.8)) and ≥75 (199(13,375)) CONCLUSIONS: The high burden of RSV hospitalizations among young children and seniors age ≥75 suggests the need for additional control measures such as vaccination to mitigate the impact of annual RSV epidemics. Our estimates for influenza-associated hospitalizations provide further evidence of the burden of morbidity associated with influenza, supporting current guidelines regarding influenza vaccination and antiviral treatment. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; New York City; Respiratory Syncytial Virus; hospitalization
PMID: 25980600 [PubMed - as supplied by publisher]
[h=1]Estimating the hospitalization burden associated with influenza and respiratory syncytial virus in New York City, 2003-2011.[/h] Goldstein E[SUP]1[/SUP], Greene SK[SUP]2[/SUP], Olson DR[SUP]3[/SUP], Hanage WP[SUP]1[/SUP], Lipsitch M[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Hospitalization burden associated with influenza and respiratory syncytial virus (RSV) is uncertain due to ambiguity in the inference methodologies employed for its estimation.
[h=4]OBJECTIVES:[/h] Utilization of a new method to quantify the above burden.
[h=4]METHODS:[/h] Weekly hospitalization rates for several principal diagnoses from 2003-2011 in New York City by age group were regressed linearly against incidence proxies for the major influenza subtypes and RSV adjusting for temporal trends and seasonal baselines.
[h=4]RESULTS:[/h] Average annual rates of influenza-associated respiratory hospitalizations per 100,000 were estimated to be 129(95% CI (79,179)) for age <1, 36.3(21.6,51.4) for ages 1-4, 10.6(7.5,13.7) for ages 5-17, 25.6(21.3,29.8) for ages 18-49, 65.5(54.0,76.9) for ages 50-64, 125(105,147) for ages 65-74, and 288(244,331) for ages ≥75. Additionally, influenza had a significant contribution to hospitalization rates with a principal diagnosis of septicemia for ages 5-17 (0.76(0.1,1.4)), 18-49 (1.02(0.3,1.7)), 50-64 (4.0(1.7,6.3)), 65-74 (8.8(2.2,15.6)) and ≥75 (38.7(25.7,52.9)). RSV had a significant contribution to the rates of respiratory hospitalizations for age <1 (1900(1740,2060)), ages 1-4 (117(70,167)) and ≥75 (175(44,312)) (including chronic lower respiratory disease, 90(43,140.)) as well as pneumonia & influenza hospitalizations for ages 18-49 (6.2(1.1,11.3)) and circulatory hospitalizations for ages 1-4 (13.2(2.6,23.8)) and ≥75 (199(13,375)) CONCLUSIONS: The high burden of RSV hospitalizations among young children and seniors age ≥75 suggests the need for additional control measures such as vaccination to mitigate the impact of annual RSV epidemics. Our estimates for influenza-associated hospitalizations provide further evidence of the burden of morbidity associated with influenza, supporting current guidelines regarding influenza vaccination and antiviral treatment. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; New York City; Respiratory Syncytial Virus; hospitalization
PMID: 25980600 [PubMed - as supplied by publisher]