tetano
Editor, Senior Moderator
Clinical Infectious Diseases
Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009?April 2010)
1. Sundar S. Shrestha1,
2. David L. Swerdlow2,
3. Rebekah H. Borse3,
4. Vimalanand S. Prabhu4,
5. Lyn Finelli5,
6. Charisma Y. Atkins3,
7. Kwame Owusu-Edusei6,
8. Beth Bell2,
9. Paul S. Mead7,
10. Matthew Biggerstaff5,
11. Lynnette Brammer5,
12. Heidi Davidson5,
13. Daniel Jernigan5,
14. Michael A. Jhung5,
15. Laurie A. Kamimoto5,
16. Toby L. Merlin8,
17. Mackenzie Nowell5,
18. Stephen C. Redd8,
19. Carrie Reed5,
20. Anne Schuchat2, and
21. Martin I. Meltzer3
+ Author Affiliations
1.
1Division of Diabetes Translation
2.
2Office of the Director, National Center for Immunization and Respiratory Disease
3.
3Division of Preparedness and Emerging Infections
4.
4Division of Global HIV/AIDs
5.
5Influenza Division
6.
6Division of Sexually Transmitted Disease Prevention
7.
7Division of Vector-Borne Infectious Diseases
8.
8Office of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
1. Correspondence: Martin Meltzer, Ph.D., MS D-59, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333 (qzm4@cdc.gov).
Abstract
To calculate the burden of 2009 pandemic influenza A (pH1N1) in the United States, we extrapolated from the Centers for Disease Control and Prevention's Emerging Infections Program laboratory-confirmed hospitalizations across the entire United States, and then corrected for underreporting. From 12 April 2009 to 10 April 2010, we estimate that approximately 60.8 million cases (range: 43.3?89.3 million), 274 304 hospitalizations (195 086?402 719), and 12 469 deaths (8868?18 306) occurred in the United States due to pH1N1. Eighty-seven percent of deaths occurred in those under 65 years of age with children and working adults having risks of hospitalization and death 4 to 7 times and 8 to 12 times greater, respectively, than estimates of impact due to seasonal influenza covering the years 1976?2001. In our study, adults 65 years of age or older were found to have rates of hospitalization and death that were up to 75% and 81%, respectively, lower than seasonal influenza. These results confirm the necessity of a concerted public health response to pH1N1.
http://cid.oxfordjournals.org/content/52/suppl_1/S75.full
Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009?April 2010)
1. Sundar S. Shrestha1,
2. David L. Swerdlow2,
3. Rebekah H. Borse3,
4. Vimalanand S. Prabhu4,
5. Lyn Finelli5,
6. Charisma Y. Atkins3,
7. Kwame Owusu-Edusei6,
8. Beth Bell2,
9. Paul S. Mead7,
10. Matthew Biggerstaff5,
11. Lynnette Brammer5,
12. Heidi Davidson5,
13. Daniel Jernigan5,
14. Michael A. Jhung5,
15. Laurie A. Kamimoto5,
16. Toby L. Merlin8,
17. Mackenzie Nowell5,
18. Stephen C. Redd8,
19. Carrie Reed5,
20. Anne Schuchat2, and
21. Martin I. Meltzer3
+ Author Affiliations
1.
1Division of Diabetes Translation
2.
2Office of the Director, National Center for Immunization and Respiratory Disease
3.
3Division of Preparedness and Emerging Infections
4.
4Division of Global HIV/AIDs
5.
5Influenza Division
6.
6Division of Sexually Transmitted Disease Prevention
7.
7Division of Vector-Borne Infectious Diseases
8.
8Office of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
1. Correspondence: Martin Meltzer, Ph.D., MS D-59, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333 (qzm4@cdc.gov).
Abstract
To calculate the burden of 2009 pandemic influenza A (pH1N1) in the United States, we extrapolated from the Centers for Disease Control and Prevention's Emerging Infections Program laboratory-confirmed hospitalizations across the entire United States, and then corrected for underreporting. From 12 April 2009 to 10 April 2010, we estimate that approximately 60.8 million cases (range: 43.3?89.3 million), 274 304 hospitalizations (195 086?402 719), and 12 469 deaths (8868?18 306) occurred in the United States due to pH1N1. Eighty-seven percent of deaths occurred in those under 65 years of age with children and working adults having risks of hospitalization and death 4 to 7 times and 8 to 12 times greater, respectively, than estimates of impact due to seasonal influenza covering the years 1976?2001. In our study, adults 65 years of age or older were found to have rates of hospitalization and death that were up to 75% and 81%, respectively, lower than seasonal influenza. These results confirm the necessity of a concerted public health response to pH1N1.
http://cid.oxfordjournals.org/content/52/suppl_1/S75.full