tetano
Editor, Senior Moderator
Vaccine. 2017 Aug 24;35(36):4811-4816. doi: 10.1016/j.vaccine.2017.07.006.
[h=1]Estimating influenza disease burden among pregnant women: Application of self-control method.[/h] Ohfuji S[SUP]1[/SUP], Deguchi M[SUP]2[/SUP], Tachibana D[SUP]3[/SUP], Koyama M[SUP]3[/SUP], Takagi T[SUP]4[/SUP], Yoshioka T[SUP]5[/SUP], Urae A[SUP]6[/SUP], Fukushima W[SUP]7[/SUP], Hirota Y[SUP]8[/SUP]; Osaka Pregnant Women Influenza Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season. The hospitalization rates during pregnancy and non-pregnancy periods was calculated separately. To compare the hospitalization rate during pregnancy with that during non-pregnancy within the same single study subject, Mantel-Haenzel rate ratios (RR[SUB]MH[/SUB]) were calculated. During the four seasons examined in this study, nine and 17 subjects were hospitalized due to respiratory illnesses during pregnancy and non-pregnancy periods, respectively. The hospitalization rate was 2.54 per 10,000 woman-months during pregnancy and 1.08 per 10,000 woman-months during non-pregnancy. The RR[SUB]MH[/SUB] for the hospitalization rate during pregnancy compared with that during non-pregnancy was 4.30 (95% confidence interval, 1.96-9.41). Our results suggest that during the influenza season, pregnant women have a higher risk than non-pregnant women for hospitalization due to respiratory illnesses. The self-control method appears to be an appropriate epidemiological method for evaluating the disease burden of influenza among pregnant women.
Copyright ? 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Disease burden; Influenza; Pregnant women; Self-control method
PMID: 28818474 DOI: 10.1016/j.vaccine.2017.07.006
[h=1]Estimating influenza disease burden among pregnant women: Application of self-control method.[/h] Ohfuji S[SUP]1[/SUP], Deguchi M[SUP]2[/SUP], Tachibana D[SUP]3[/SUP], Koyama M[SUP]3[/SUP], Takagi T[SUP]4[/SUP], Yoshioka T[SUP]5[/SUP], Urae A[SUP]6[/SUP], Fukushima W[SUP]7[/SUP], Hirota Y[SUP]8[/SUP]; Osaka Pregnant Women Influenza Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season. The hospitalization rates during pregnancy and non-pregnancy periods was calculated separately. To compare the hospitalization rate during pregnancy with that during non-pregnancy within the same single study subject, Mantel-Haenzel rate ratios (RR[SUB]MH[/SUB]) were calculated. During the four seasons examined in this study, nine and 17 subjects were hospitalized due to respiratory illnesses during pregnancy and non-pregnancy periods, respectively. The hospitalization rate was 2.54 per 10,000 woman-months during pregnancy and 1.08 per 10,000 woman-months during non-pregnancy. The RR[SUB]MH[/SUB] for the hospitalization rate during pregnancy compared with that during non-pregnancy was 4.30 (95% confidence interval, 1.96-9.41). Our results suggest that during the influenza season, pregnant women have a higher risk than non-pregnant women for hospitalization due to respiratory illnesses. The self-control method appears to be an appropriate epidemiological method for evaluating the disease burden of influenza among pregnant women.
Copyright ? 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Disease burden; Influenza; Pregnant women; Self-control method
PMID: 28818474 DOI: 10.1016/j.vaccine.2017.07.006