tetano
Editor, Senior Moderator
ESC Heart Fail
. 2022 Nov 19.
doi: 10.1002/ehf2.14228. Online ahead of print.
Fulminant myocarditis with COVID-19 infection having normal C-reactive protein and serial magnetic resonance follow-up
Eisuke Usui[SUP] 1 [/SUP], Eiki Nagaoka[SUP] 2 [/SUP], Hiroshi Ikeda[SUP] 1 [/SUP], Mari Ohmori[SUP] 1 [/SUP], Susumu Tao[SUP] 1 [/SUP], Taishi Yonetsu[SUP] 1 [/SUP], Yasuhiro Maejima[SUP] 1 [/SUP], Hirokuni Arai[SUP] 2 [/SUP], Kisaki Amemiya[SUP] 3 [/SUP], Yoshihiko Ikeda[SUP] 3 [/SUP], Tetsuo Sasano[SUP] 1 [/SUP]
Affiliations
Abstract
A 44-year-old woman who was quarantined for 5 days after the diagnosis of coronavirus disease of 2019 (COVID-19) was transferred to our hospital with the complaint of chest pain. The patient was unvaccinated. Electrocardiography revealed ST elevation in the lateral leads. Echocardiographic biventricular dysfunction with oedematous wall thickening was identified. Cardiac enzyme levels were elevated; however, C-reactive protein (CRP) levels, and the coronary angiogram were normal. The patient required mechanical circulatory support to stabilize haemodynamics and was treated with remdesivir, baricitinib, and intravenous methylprednisolone. She recovered after 13 days of mechanical support. Serial cardiac magnetic resonance imaging revealed acute myocardial oedema and subsequent fibrosis. An endomyocardial biopsy on admission showed mild interstitial inflammatory infiltrates with endomyocardial fibrous thickening and mild interstitial fibrosis of the myocardium. Normal CRP levels suggested minor involvement of interleukin (IL)-6, supporting the efficacy of baricitinib.
Keywords: C-reactive protein; COVID-19; Cardiac magnetic resonance; Fulminant myocarditis.
. 2022 Nov 19.
doi: 10.1002/ehf2.14228. Online ahead of print.
Fulminant myocarditis with COVID-19 infection having normal C-reactive protein and serial magnetic resonance follow-up
Eisuke Usui[SUP] 1 [/SUP], Eiki Nagaoka[SUP] 2 [/SUP], Hiroshi Ikeda[SUP] 1 [/SUP], Mari Ohmori[SUP] 1 [/SUP], Susumu Tao[SUP] 1 [/SUP], Taishi Yonetsu[SUP] 1 [/SUP], Yasuhiro Maejima[SUP] 1 [/SUP], Hirokuni Arai[SUP] 2 [/SUP], Kisaki Amemiya[SUP] 3 [/SUP], Yoshihiko Ikeda[SUP] 3 [/SUP], Tetsuo Sasano[SUP] 1 [/SUP]
Affiliations
- PMID: 36401586
- DOI: 10.1002/ehf2.14228
Abstract
A 44-year-old woman who was quarantined for 5 days after the diagnosis of coronavirus disease of 2019 (COVID-19) was transferred to our hospital with the complaint of chest pain. The patient was unvaccinated. Electrocardiography revealed ST elevation in the lateral leads. Echocardiographic biventricular dysfunction with oedematous wall thickening was identified. Cardiac enzyme levels were elevated; however, C-reactive protein (CRP) levels, and the coronary angiogram were normal. The patient required mechanical circulatory support to stabilize haemodynamics and was treated with remdesivir, baricitinib, and intravenous methylprednisolone. She recovered after 13 days of mechanical support. Serial cardiac magnetic resonance imaging revealed acute myocardial oedema and subsequent fibrosis. An endomyocardial biopsy on admission showed mild interstitial inflammatory infiltrates with endomyocardial fibrous thickening and mild interstitial fibrosis of the myocardium. Normal CRP levels suggested minor involvement of interleukin (IL)-6, supporting the efficacy of baricitinib.
Keywords: C-reactive protein; COVID-19; Cardiac magnetic resonance; Fulminant myocarditis.