tetano
Editor, Senior Moderator
ERJ Open Res
. 2021 Mar 8;7(1):00888-2020.
doi: 10.1183/23120541.00888-2020. eCollection 2021 Jan.
Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia
Gerard Moreno[SUP] 1 2 [/SUP], Alejandro Rodr?guez[SUP] 1 2 [/SUP], Jordi Sole-Viol?n[SUP] 3 [/SUP], Ignacio Mart?n-Loeches[SUP] 4 [/SUP], Emili D?az[SUP] 5 [/SUP], Mar?a Bod?[SUP] 1 [/SUP], Luis F Reyes[SUP] 6 [/SUP], Josep G?mez[SUP] 1 [/SUP], Juan Guardiola[SUP] 7 [/SUP], Sandra Trefler[SUP] 1 [/SUP], Loreto Vidaur[SUP] 8 [/SUP], Elisabet Papiol[SUP] 9 [/SUP], Lorenzo Socias[SUP] 10 [/SUP], Carolina Garc?a-Vidal[SUP] 11 [/SUP], Eudald Correig[SUP] 1 [/SUP], Judith Mar?n-Corral[SUP] 12 [/SUP], Marcos I Restrepo[SUP] 13 [/SUP], Jonathan S Nguyen-Van-Tam[SUP] 14 [/SUP], Antoni Torres[SUP] 15 16 [/SUP]
Affiliations
Abstract
Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration.
. 2021 Mar 8;7(1):00888-2020.
doi: 10.1183/23120541.00888-2020. eCollection 2021 Jan.
Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia
Gerard Moreno[SUP] 1 2 [/SUP], Alejandro Rodr?guez[SUP] 1 2 [/SUP], Jordi Sole-Viol?n[SUP] 3 [/SUP], Ignacio Mart?n-Loeches[SUP] 4 [/SUP], Emili D?az[SUP] 5 [/SUP], Mar?a Bod?[SUP] 1 [/SUP], Luis F Reyes[SUP] 6 [/SUP], Josep G?mez[SUP] 1 [/SUP], Juan Guardiola[SUP] 7 [/SUP], Sandra Trefler[SUP] 1 [/SUP], Loreto Vidaur[SUP] 8 [/SUP], Elisabet Papiol[SUP] 9 [/SUP], Lorenzo Socias[SUP] 10 [/SUP], Carolina Garc?a-Vidal[SUP] 11 [/SUP], Eudald Correig[SUP] 1 [/SUP], Judith Mar?n-Corral[SUP] 12 [/SUP], Marcos I Restrepo[SUP] 13 [/SUP], Jonathan S Nguyen-Van-Tam[SUP] 14 [/SUP], Antoni Torres[SUP] 15 16 [/SUP]
Affiliations
- PMID: 33718494
- PMCID: PMC7938052
- DOI: 10.1183/23120541.00888-2020
Abstract
Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration.