tetano
Editor, Senior Moderator
Epilepsy Behav
. 2021 Mar 17;118:107887.
doi: 10.1016/j.yebeh.2021.107887. Online ahead of print.
Status epilepticus and COVID-19: A systematic review
Fedele Dono[SUP] 1 [/SUP], Bruna Nucera[SUP] 2 [/SUP], Jacopo Lanzone[SUP] 3 [/SUP], Giacomo Evangelista[SUP] 1 [/SUP], Fabrizio Rinaldi[SUP] 2 [/SUP], Rino Speranza[SUP] 1 [/SUP], Serena Troisi[SUP] 4 [/SUP], Lorenzo Tinti[SUP] 5 [/SUP], Mirella Russo[SUP] 1 [/SUP], Martina Di Pietro[SUP] 1 [/SUP], Marco Onofrj[SUP] 1 [/SUP], Laura Bonanni[SUP] 1 [/SUP], Giovanni Assenza[SUP] 6 [/SUP], Catello Vollono[SUP] 7 [/SUP], Francesca Anzellotti[SUP] 8 [/SUP], Francesco Brigo[SUP] 2 [/SUP]
Affiliations
Abstract
Purpose: In March 2020, the World Health Organization declared the SARS-CoV-2 infection-related coronavirus Disease (COVID-19) a pandemic. During the first and second waves of the pandemic spread, there have been several reports of COVID-19-associated neurological manifestations, including acute seizures and status epilepticus (SE). In this systematic review, we summarized the available data on clinical features, diagnosis, and therapy of COVID-19-related SE.
Methods: We performed a systematic search of the literature to identify data on demographics, clinical, neurophysiological, and neuroradiological data of patients with COVID-19-related SE. We used regression models (linear or logistic) with a stepwise forward method to identify features associated with mortality or severity of SE.
Results: Thirty-nine articles were included with a total of 47 cases of SE associated with COVID-19. Age, time between the acute respiratory phase of SARS-CoV-2 infection and SE onset, and hospitalization correlated with a higher SE severity as assessed by quantitative validated scales.
Conclusions: SE can be a neurological manifestation of SARS-CoV-2 infection. Although a possible association between SE and COVID-19 has been reported, the exact mechanisms are still not fully understood. Systemic inflammatory syndrome due to cytokine release could play a role in COVID-19-related SE.
Keywords: Epilepsy; Pandemic; SARS-CoV-2 infection; Status epilepticus.
. 2021 Mar 17;118:107887.
doi: 10.1016/j.yebeh.2021.107887. Online ahead of print.
Status epilepticus and COVID-19: A systematic review
Fedele Dono[SUP] 1 [/SUP], Bruna Nucera[SUP] 2 [/SUP], Jacopo Lanzone[SUP] 3 [/SUP], Giacomo Evangelista[SUP] 1 [/SUP], Fabrizio Rinaldi[SUP] 2 [/SUP], Rino Speranza[SUP] 1 [/SUP], Serena Troisi[SUP] 4 [/SUP], Lorenzo Tinti[SUP] 5 [/SUP], Mirella Russo[SUP] 1 [/SUP], Martina Di Pietro[SUP] 1 [/SUP], Marco Onofrj[SUP] 1 [/SUP], Laura Bonanni[SUP] 1 [/SUP], Giovanni Assenza[SUP] 6 [/SUP], Catello Vollono[SUP] 7 [/SUP], Francesca Anzellotti[SUP] 8 [/SUP], Francesco Brigo[SUP] 2 [/SUP]
Affiliations
- PMID: 33743344
- DOI: 10.1016/j.yebeh.2021.107887
Abstract
Purpose: In March 2020, the World Health Organization declared the SARS-CoV-2 infection-related coronavirus Disease (COVID-19) a pandemic. During the first and second waves of the pandemic spread, there have been several reports of COVID-19-associated neurological manifestations, including acute seizures and status epilepticus (SE). In this systematic review, we summarized the available data on clinical features, diagnosis, and therapy of COVID-19-related SE.
Methods: We performed a systematic search of the literature to identify data on demographics, clinical, neurophysiological, and neuroradiological data of patients with COVID-19-related SE. We used regression models (linear or logistic) with a stepwise forward method to identify features associated with mortality or severity of SE.
Results: Thirty-nine articles were included with a total of 47 cases of SE associated with COVID-19. Age, time between the acute respiratory phase of SARS-CoV-2 infection and SE onset, and hospitalization correlated with a higher SE severity as assessed by quantitative validated scales.
Conclusions: SE can be a neurological manifestation of SARS-CoV-2 infection. Although a possible association between SE and COVID-19 has been reported, the exact mechanisms are still not fully understood. Systemic inflammatory syndrome due to cytokine release could play a role in COVID-19-related SE.
Keywords: Epilepsy; Pandemic; SARS-CoV-2 infection; Status epilepticus.