tetano
Editor, Senior Moderator
Epilepsy Behav
. 2021 Nov 15;125:108437.
doi: 10.1016/j.yebeh.2021.108437. Online ahead of print.
Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
Yusak Mangara Tua Siahaan[SUP] 1 [/SUP], Retno Jayantri Ketaren[SUP] 1 [/SUP], Vinson Hartoyo[SUP] 1 [/SUP], Timotius Ivan Hariyanto[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Patients with epilepsy experience seizures, which have been reported to increase and worsen during the coronavirus disease (COVID-19) pandemic. However, the association between epilepsy and COVID-19 outcomes remains unclear. The aim of this study was to analyze whether patients with epilepsy have an increased risk of having poor COVID-19 outcomes.
Methods: We comprehensively evaluated potential articles extracted from the medRxiv, Europe PMC, and PubMed databases until June 30, 2021, using selected keywords. All published studies on epilepsy and COVID-19 were selected. We used the Review Manager 5.4 and Comprehensive Meta-Analysis 3 software for statistical analysis.
Results: Thirteen studies with 67,131 patients with COVID-19 were included in the analysis. Evaluation of the collated data revealed an association between epilepsy and increased severity of COVID-19 (OR, 1.69; 95%CI: 1.11-2.59; p = 0.010; I[SUP]2[/SUP] = 29%; random-effect modeling) and mortality from COVID-19 (OR, 1.71; 95%CI: 1.14-2.56; p = 0.010; I[SUP]2[/SUP] = 53%; random-effect modeling). The results also showed that the association between epilepsy and increased risk of developing severe COVID-19 is influenced by sex and neurodegenerative disease.
Conclusions: The findings of this study suggest that patients with epilepsy are at risk of having poor COVID-19 outcomes. Patients with epilepsy need special attention and should be prioritized for administration of the COVID-19 vaccine. Registration details: PROSPERO (CRD42021264979).
Keywords: COVID-19; Coronavirus disease 2019; Epilepsy; Neurology; Seizure.
. 2021 Nov 15;125:108437.
doi: 10.1016/j.yebeh.2021.108437. Online ahead of print.
Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
Yusak Mangara Tua Siahaan[SUP] 1 [/SUP], Retno Jayantri Ketaren[SUP] 1 [/SUP], Vinson Hartoyo[SUP] 1 [/SUP], Timotius Ivan Hariyanto[SUP] 2 [/SUP]
Affiliations
- PMID: 34839246
- DOI: 10.1016/j.yebeh.2021.108437
Abstract
Background: Patients with epilepsy experience seizures, which have been reported to increase and worsen during the coronavirus disease (COVID-19) pandemic. However, the association between epilepsy and COVID-19 outcomes remains unclear. The aim of this study was to analyze whether patients with epilepsy have an increased risk of having poor COVID-19 outcomes.
Methods: We comprehensively evaluated potential articles extracted from the medRxiv, Europe PMC, and PubMed databases until June 30, 2021, using selected keywords. All published studies on epilepsy and COVID-19 were selected. We used the Review Manager 5.4 and Comprehensive Meta-Analysis 3 software for statistical analysis.
Results: Thirteen studies with 67,131 patients with COVID-19 were included in the analysis. Evaluation of the collated data revealed an association between epilepsy and increased severity of COVID-19 (OR, 1.69; 95%CI: 1.11-2.59; p = 0.010; I[SUP]2[/SUP] = 29%; random-effect modeling) and mortality from COVID-19 (OR, 1.71; 95%CI: 1.14-2.56; p = 0.010; I[SUP]2[/SUP] = 53%; random-effect modeling). The results also showed that the association between epilepsy and increased risk of developing severe COVID-19 is influenced by sex and neurodegenerative disease.
Conclusions: The findings of this study suggest that patients with epilepsy are at risk of having poor COVID-19 outcomes. Patients with epilepsy need special attention and should be prioritized for administration of the COVID-19 vaccine. Registration details: PROSPERO (CRD42021264979).
Keywords: COVID-19; Coronavirus disease 2019; Epilepsy; Neurology; Seizure.