tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2013 Dec 30. doi: 10.1111/1469-0691.12525. [Epub ahead of print]
'Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011-2012'
Ambrosioni J, Bridevaux PO, Wagner G, Mamin A, Kaiser L.
Author information
Abstract
Few studies have examined the epidemiology of respiratory viral infections in large tertiary centres over more than one season in the era of molecular diagnosis. Respiratory clinical specimens received between 01/01/2011 and 31/12/2012 were analysed. Respiratory virus testing was performed using a large panel of real-time polymerase chain reaction (PCR) or reverse-transcriptase (RT) PCR. Results were analyzed according to sample type (upper versus lower respiratory tract) and age group. In all, 2996 (2469 [82.4%] upper; 527 [17.6%] lower) specimens were analyzed. Overall positivity rate (PR) was 47.4% and 23.7% for upper and lower respiratory samples, respectively. The highest PR was observed in patients under 18 yo (p<0.001); picornaviruses were the most frequent viruses detected over the year. Influenza, respiratory syncytial virus, human metapneumovirus and coronaviruses showed a seasonal peak during the winter season, while picornaviruses and adenoviruses were less frequently detected in these periods. Multiple viral infections were identified in approximately 12% of cases and were significantly more frequent in children (p<0.001). In conclusion, we observed significant differences in viral infection rates and virus types among age groups, clinical sample types, and seasons. Follow-up of viral detection over several seasons allows a better understanding of respiratory viral epidemiology. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID:
24382326
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24382326
'Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011-2012'
Ambrosioni J, Bridevaux PO, Wagner G, Mamin A, Kaiser L.
Author information
Abstract
Few studies have examined the epidemiology of respiratory viral infections in large tertiary centres over more than one season in the era of molecular diagnosis. Respiratory clinical specimens received between 01/01/2011 and 31/12/2012 were analysed. Respiratory virus testing was performed using a large panel of real-time polymerase chain reaction (PCR) or reverse-transcriptase (RT) PCR. Results were analyzed according to sample type (upper versus lower respiratory tract) and age group. In all, 2996 (2469 [82.4%] upper; 527 [17.6%] lower) specimens were analyzed. Overall positivity rate (PR) was 47.4% and 23.7% for upper and lower respiratory samples, respectively. The highest PR was observed in patients under 18 yo (p<0.001); picornaviruses were the most frequent viruses detected over the year. Influenza, respiratory syncytial virus, human metapneumovirus and coronaviruses showed a seasonal peak during the winter season, while picornaviruses and adenoviruses were less frequently detected in these periods. Multiple viral infections were identified in approximately 12% of cases and were significantly more frequent in children (p<0.001). In conclusion, we observed significant differences in viral infection rates and virus types among age groups, clinical sample types, and seasons. Follow-up of viral detection over several seasons allows a better understanding of respiratory viral epidemiology. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID:
24382326
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24382326