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Epidemiology of pandemic influenza A/H1N1 virus during 2009-2010 in Taiwan

tetano

Editor, Senior Moderator
Virus Res. 2013 Jul 22. pii: S0168-1702(13)00229-3. doi: 10.1016/j.virusres.2013.07.007. [Epub ahead of print]
Epidemiology of pandemic influenza A/H1N1 virus during 2009-2010 in Taiwan.
Lan YC, Su MC, Chen CH, Huang SH, Chen WL, Tien N, Lin CW.
Source

Department of Health Risk Management, School of Public, China Medical University, Taichung, Taiwan.
Abstract

Outbreak of swine-origin influenza A/H1N1 virus (pdmH1N1) occurred in 2009. Taiwanese authorities implemented nationwide vaccinations with pdmH1N1-specific inactivated vaccine as of November 2009. This study evaluates prevalence, HA phylogenetic relationship, and transmission dynamic of influenza A and B viruses in Taiwan in 2009-2010. Respiratory tract specimens were analyzed for influenza A and B viruses. The pdmH1N1 peaked in November 2009, was predominant from August 2009 to January 2010, then sharply dropped in February 2010. Significant prevalence peaks of influenza B in April-June of 2010 and H3N2 virus in July and August were observed. Highest percentage of pdmH1N1- and H3N2-positive cases appeared among 11-15-year-olds; influenza B-positive cases were dominant among those 6-10 years old. Maximum Likelihood phylogenetic trees showed 11 unique clusters of pdmH1N1, seasonal H3N2 influenza A and B viruses, as well as transmission clusters and mixed infections of influenza strains in Taiwan. The 2009 pdmH1N1 virus was predominant in Taiwan from August 2009 to January 2010; seasonal H3N2 influenza A and B viruses exhibited small prevalence peaks after nationwide vaccinations. Phylogenetic evidence indicated transmission clusters and multiple independent clades of co-circulating influenza A and B strains in Taiwan.

Copyright ? 2013 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:

HA subtyping, mixed infection, pandemic influenza, phylogenetic analysis, surveillance

PMID:
23886669
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23886669
 
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