tetano
Editor, Senior Moderator
PLoS One. 2016 May 19;11(5):e0154970. doi: 10.1371/journal.pone.0154970. eCollection 2016.
[h=1]Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network.[/h] Puig-Barber? J[SUP]1[/SUP], Natividad-Sancho A[SUP]1[/SUP], Trushakova S[SUP]2[/SUP], Sominina A[SUP]3[/SUP], Pisareva M[SUP]3[/SUP], Ciblak MA[SUP]4[/SUP], Badur S[SUP]4[/SUP], Yu H[SUP]5[/SUP], Cowling BJ[SUP]6[/SUP], El Guerche-S?blain C[SUP]7[/SUP], Mira-Iglesias A[SUP]1[/SUP], Kisteneva L[SUP]2[/SUP], Stolyarov K[SUP]3[/SUP], Yurtcu K[SUP]4[/SUP], Feng L[SUP]5[/SUP], L?pez-Labrador X[SUP]1,[/SUP][SUP]8[/SUP], Burtseva E[SUP]2[/SUP]; Global Influenza Hospital Surveillance Study Group (GIHSN).
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.
[h=4]METHODS:[/h] Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.
[h=4]FINDINGS:[/h] 5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).
[h=4]CONCLUSIONS:[/h] Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.
PMID: 27196667 [PubMed - in process] Free full text
[h=1]Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network.[/h] Puig-Barber? J[SUP]1[/SUP], Natividad-Sancho A[SUP]1[/SUP], Trushakova S[SUP]2[/SUP], Sominina A[SUP]3[/SUP], Pisareva M[SUP]3[/SUP], Ciblak MA[SUP]4[/SUP], Badur S[SUP]4[/SUP], Yu H[SUP]5[/SUP], Cowling BJ[SUP]6[/SUP], El Guerche-S?blain C[SUP]7[/SUP], Mira-Iglesias A[SUP]1[/SUP], Kisteneva L[SUP]2[/SUP], Stolyarov K[SUP]3[/SUP], Yurtcu K[SUP]4[/SUP], Feng L[SUP]5[/SUP], L?pez-Labrador X[SUP]1,[/SUP][SUP]8[/SUP], Burtseva E[SUP]2[/SUP]; Global Influenza Hospital Surveillance Study Group (GIHSN).
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.
[h=4]METHODS:[/h] Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.
[h=4]FINDINGS:[/h] 5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).
[h=4]CONCLUSIONS:[/h] Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.
PMID: 27196667 [PubMed - in process] Free full text