tetano
Editor, Senior Moderator
Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Jul;32(7):661-663.
[Epidemiological effects of the A (H1N1) influenza vaccine immunization program on students.]
[Article in Chinese]
He HQ, Li Q, He B, Gao WJ, Yao FY, Jiang XF, Shen YG, Zhou JH, Chen EF.
Source
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. Email: hhqcdc@163.com.
Abstract
OBJECTIVE:
To evaluate the epidemiological effects of vaccine immunization program related to A (H1N1) influenza in the middle school students.
METHODS:
Non-randomized clinical trial was designed to assess the A (H1N1) influenza vaccine on its efficacy. 14 883 students from 8 middle schools in Zhejiang province were recruited and classified into vaccinated or control groups, based on the status of immunization with A (H1N1) influenza vaccine. All subjects were followed up through one epidemic period (6 months) and the incidence rates of influenza-like illnesses, A (H1N1) influenza, and seasonal influenza in these two groups were compared to evaluate the efficacy of the vaccine.
RESULTS:
There were 6334 subjects in the vaccinated group and 8549 in the control group. 7441.75 person-years were followed from these two groups. The incidence rate of A (H1N1) influenza in vaccinated group was 1.64? per person-year, lower than that of the control group. The rate difference (RD) was -1.64? per person-year (95% confidence interval value from -3.04? to -0.23? per person-year), and the difference was significant (P = 0.010). The incidence rate of influenza-like illnesses in vaccinated group was 21.47? per person-year, lower than that of the control group (22.69? per person-year) and the difference was not significant (P > 0.05). The incidence rate of B influenza in vaccinated group was 6.63? per person-year, higher than that of control group (7.02? per person-year) but the difference was not significant (P > 0.05).
CONCLUSION:
This vaccine demonstrated a good epidemiological effect against the A (H1N1) influenza virus infection, observed through a student-immunization program. The cross-protection effect against the influenza-like illnesses and other seasonal influenzas was not noticed in this study.
PMID:
21933534
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21933534
[Epidemiological effects of the A (H1N1) influenza vaccine immunization program on students.]
[Article in Chinese]
He HQ, Li Q, He B, Gao WJ, Yao FY, Jiang XF, Shen YG, Zhou JH, Chen EF.
Source
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. Email: hhqcdc@163.com.
Abstract
OBJECTIVE:
To evaluate the epidemiological effects of vaccine immunization program related to A (H1N1) influenza in the middle school students.
METHODS:
Non-randomized clinical trial was designed to assess the A (H1N1) influenza vaccine on its efficacy. 14 883 students from 8 middle schools in Zhejiang province were recruited and classified into vaccinated or control groups, based on the status of immunization with A (H1N1) influenza vaccine. All subjects were followed up through one epidemic period (6 months) and the incidence rates of influenza-like illnesses, A (H1N1) influenza, and seasonal influenza in these two groups were compared to evaluate the efficacy of the vaccine.
RESULTS:
There were 6334 subjects in the vaccinated group and 8549 in the control group. 7441.75 person-years were followed from these two groups. The incidence rate of A (H1N1) influenza in vaccinated group was 1.64? per person-year, lower than that of the control group. The rate difference (RD) was -1.64? per person-year (95% confidence interval value from -3.04? to -0.23? per person-year), and the difference was significant (P = 0.010). The incidence rate of influenza-like illnesses in vaccinated group was 21.47? per person-year, lower than that of the control group (22.69? per person-year) and the difference was not significant (P > 0.05). The incidence rate of B influenza in vaccinated group was 6.63? per person-year, higher than that of control group (7.02? per person-year) but the difference was not significant (P > 0.05).
CONCLUSION:
This vaccine demonstrated a good epidemiological effect against the A (H1N1) influenza virus infection, observed through a student-immunization program. The cross-protection effect against the influenza-like illnesses and other seasonal influenzas was not noticed in this study.
PMID:
21933534
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21933534