tetano
Editor, Senior Moderator
Fetal Pediatr Pathol. 2019 Jul 3:1-8. doi: 10.1080/15513815.2019.1636429. [Epub ahead of print]
[h=1]Epidemiological and Immunological Features of Influenza Viruses in Hospitalized Children with Influenza Illness in Hangzhou.[/h] Li W[SUP]1[/SUP], Liu LF[SUP]1[/SUP], Xu JL[SUP]1[/SUP], Shang SQ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objectives: We evaluated the epidemiological features and various inflammatory markers in hospitalized children with influenza virus infection in China. Methods: The real-time RT-PCR assay was performed for detection and genotyping of influenza A and B virus. Th1/Th2 cytokines, WBC, and CRP were determined in influenza virus positive children. Results: H1N1 and Yamagata were the prevalent genotypes of influenza A and B virus in Hangzhou, respectively. IL-2, IL-10, and CRP were significantly increased and IFN-γ was decreased in children with severe Influenza A virus infection, and TNF-α and IFN-γ levels were found to be significantly lower in children with severe Influenza B virus infection. Conclusion: Increased IL-2, IL-10, and CRP with decreased IFN-γ may indicate a severe influenza A virus infection, and decreased TNF-α and IFN-γ may indicate a severe influenza B virus infection in children.
[h=4]KEYWORDS:[/h] cytokines; hospitalized children; influenza
PMID: 31268384 DOI: 10.1080/15513815.2019.1636429
[h=1]Epidemiological and Immunological Features of Influenza Viruses in Hospitalized Children with Influenza Illness in Hangzhou.[/h] Li W[SUP]1[/SUP], Liu LF[SUP]1[/SUP], Xu JL[SUP]1[/SUP], Shang SQ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objectives: We evaluated the epidemiological features and various inflammatory markers in hospitalized children with influenza virus infection in China. Methods: The real-time RT-PCR assay was performed for detection and genotyping of influenza A and B virus. Th1/Th2 cytokines, WBC, and CRP were determined in influenza virus positive children. Results: H1N1 and Yamagata were the prevalent genotypes of influenza A and B virus in Hangzhou, respectively. IL-2, IL-10, and CRP were significantly increased and IFN-γ was decreased in children with severe Influenza A virus infection, and TNF-α and IFN-γ levels were found to be significantly lower in children with severe Influenza B virus infection. Conclusion: Increased IL-2, IL-10, and CRP with decreased IFN-γ may indicate a severe influenza A virus infection, and decreased TNF-α and IFN-γ may indicate a severe influenza B virus infection in children.
[h=4]KEYWORDS:[/h] cytokines; hospitalized children; influenza
PMID: 31268384 DOI: 10.1080/15513815.2019.1636429