Giuseppe
Emeritus
What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1? (Epidemiol Infect., abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
Epidemiol Infect. 2010 Mar 18:1-9. [Epub ahead of print]
What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
Horby P, Sudoyo H, Viprakasit V, Fox A, Thai PQ, Yu H, Davila S, Hibberd M, Dunstan SJ, Monteerarat Y, Farrar JJ, Marzuki S, Hien NT. - Oxford University Clinical Research Unit, Vietnam.
SUMMARY
The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.
PMID: 20236573 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
Epidemiol Infect. 2010 Mar 18:1-9. [Epub ahead of print]
What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
Horby P, Sudoyo H, Viprakasit V, Fox A, Thai PQ, Yu H, Davila S, Hibberd M, Dunstan SJ, Monteerarat Y, Farrar JJ, Marzuki S, Hien NT. - Oxford University Clinical Research Unit, Vietnam.
SUMMARY
The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.
PMID: 20236573 [PubMed - as supplied by publisher]
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