tetano
Editor, Senior Moderator
Environ Res
. 2022 Mar 5;113062.
doi: 10.1016/j.envres.2022.113062. Online ahead of print.
Meta-analysis to explain unknown causes of the origins of SARS-COV-2
Mario Coccia[SUP] 1 [/SUP]
Affiliations
Abstract
New Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the Coronavirus Disease 2019 (COVID-19), an infectious illness that has generated a pandemic crisis worldwide. One of the fundamental questions in science and society is how SARS-CoV-2 has been originated to design best practices directed to prevent and/or to cope with future hazardous pathogens. The study confronts this question here developing a meta-analysis, which endeavors to explain and assess whenever possible, unknown sources of the SARS-CoV-2. Findings suggest that the natural spillover of novel viral agents that generate more than 5.90 M deaths in about two years (such as SARS-CoV-2 from February 2020 to March 2022) has a remote probability of occurrence (using an analogy with the probability of natural disasters), whereas science advances on hazardous viral agents and consequential lab accident have a (higher) probability of occurrence (about 13-20% like in manifold lab accidents). The findings of this meta-analysis suggest the vital role of improving the technical guidelines of biosafety at all levels in laboratories for scientific research and testing of hazardous pathogens to minimize biosecurity risks and pandemic threats in society.
Keywords: Biosecurity risks; COVID-19; Coronavirus; Emerging infectious disease; Hazardous pathogens; Laboratory biosafety; Meta-analysis; SARS-CoV-2.
. 2022 Mar 5;113062.
doi: 10.1016/j.envres.2022.113062. Online ahead of print.
Meta-analysis to explain unknown causes of the origins of SARS-COV-2
Mario Coccia[SUP] 1 [/SUP]
Affiliations
- PMID: 35259407
- DOI: 10.1016/j.envres.2022.113062
Abstract
New Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the Coronavirus Disease 2019 (COVID-19), an infectious illness that has generated a pandemic crisis worldwide. One of the fundamental questions in science and society is how SARS-CoV-2 has been originated to design best practices directed to prevent and/or to cope with future hazardous pathogens. The study confronts this question here developing a meta-analysis, which endeavors to explain and assess whenever possible, unknown sources of the SARS-CoV-2. Findings suggest that the natural spillover of novel viral agents that generate more than 5.90 M deaths in about two years (such as SARS-CoV-2 from February 2020 to March 2022) has a remote probability of occurrence (using an analogy with the probability of natural disasters), whereas science advances on hazardous viral agents and consequential lab accident have a (higher) probability of occurrence (about 13-20% like in manifold lab accidents). The findings of this meta-analysis suggest the vital role of improving the technical guidelines of biosafety at all levels in laboratories for scientific research and testing of hazardous pathogens to minimize biosecurity risks and pandemic threats in society.
Keywords: Biosecurity risks; COVID-19; Coronavirus; Emerging infectious disease; Hazardous pathogens; Laboratory biosafety; Meta-analysis; SARS-CoV-2.