tetano
Editor, Senior Moderator
Environ Microbiol
. 2022 May 4.
doi: 10.1111/1462-2920.16028. Online ahead of print.
Taxonomical and functional changes in COVID-19 faecal microbiome could be related to SARS-CoV-2 faecal load
Lucia Grenga[SUP] 1 [/SUP], Olivier Pible[SUP] 1 [/SUP], Guylaine Miotello[SUP] 1 [/SUP], Karen Culotta[SUP] 1 [/SUP], Sylvie Ruat[SUP] 1 [/SUP], Marie-Anne Roncato[SUP] 1 [/SUP], Fabienne Gas[SUP] 1 [/SUP], Laurent Bellanger[SUP] 1 [/SUP], Pierre-Géraud Claret[SUP] 2 [/SUP], Catherine Dunyach-Remy[SUP] 3 [/SUP], Didier Laureillard[SUP] 4 [/SUP], Albert Sotto[SUP] 5 [/SUP], Jean-Philippe Lavigne[SUP] 3 [/SUP], Jean Armengaud[SUP] 1 [/SUP]
Affiliations
Abstract
Since the beginning of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the gastro-intestinal (GI) tract has emerged as an important organ influencing the propensity to and potentially the severity of the related COVID-19 disease. However, the contribution of the SARS-CoV-2 intestinal infection on COVID-19 pathogenesis remains to be clarified. In this exploratory study, we highlighted a possible link between alterations in the composition of the gut microbiota and the levels of SARS-CoV-2 RNA in the gastrointestinal tract, which could be more important than the presence of SARS-CoV-2 in the respiratory tract, COVID-19 severity and GI symptoms. As established by metaproteomics, altered molecular functions in the microbiota profiles of high SARS-CoV-2 RNA level faeces highlight mechanisms such as inflammation-induced enterocyte damage, increased intestinal permeability and activation of immune response that may contribute to vicious cycles. Uncovering the role of this gut microbiota dysbiosis could drive the investigation of alternative therapeutic strategies to favour the clearance of the virus and potentially mitigate the effect of the SARS-CoV-2 infection. This article is protected by copyright. All rights reserved.
. 2022 May 4.
doi: 10.1111/1462-2920.16028. Online ahead of print.
Taxonomical and functional changes in COVID-19 faecal microbiome could be related to SARS-CoV-2 faecal load
Lucia Grenga[SUP] 1 [/SUP], Olivier Pible[SUP] 1 [/SUP], Guylaine Miotello[SUP] 1 [/SUP], Karen Culotta[SUP] 1 [/SUP], Sylvie Ruat[SUP] 1 [/SUP], Marie-Anne Roncato[SUP] 1 [/SUP], Fabienne Gas[SUP] 1 [/SUP], Laurent Bellanger[SUP] 1 [/SUP], Pierre-Géraud Claret[SUP] 2 [/SUP], Catherine Dunyach-Remy[SUP] 3 [/SUP], Didier Laureillard[SUP] 4 [/SUP], Albert Sotto[SUP] 5 [/SUP], Jean-Philippe Lavigne[SUP] 3 [/SUP], Jean Armengaud[SUP] 1 [/SUP]
Affiliations
- PMID: 35506300
- DOI: 10.1111/1462-2920.16028
Abstract
Since the beginning of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the gastro-intestinal (GI) tract has emerged as an important organ influencing the propensity to and potentially the severity of the related COVID-19 disease. However, the contribution of the SARS-CoV-2 intestinal infection on COVID-19 pathogenesis remains to be clarified. In this exploratory study, we highlighted a possible link between alterations in the composition of the gut microbiota and the levels of SARS-CoV-2 RNA in the gastrointestinal tract, which could be more important than the presence of SARS-CoV-2 in the respiratory tract, COVID-19 severity and GI symptoms. As established by metaproteomics, altered molecular functions in the microbiota profiles of high SARS-CoV-2 RNA level faeces highlight mechanisms such as inflammation-induced enterocyte damage, increased intestinal permeability and activation of immune response that may contribute to vicious cycles. Uncovering the role of this gut microbiota dysbiosis could drive the investigation of alternative therapeutic strategies to favour the clearance of the virus and potentially mitigate the effect of the SARS-CoV-2 infection. This article is protected by copyright. All rights reserved.