tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2014 Apr 22;10(7). [Epub ahead of print]
Engineered PRINT? nanoparticles for controlled delivery of antigens and immunostimulants.
Beletskii A, Galloway A, Rele S, Stone M, Malinoski F.
Author information
Abstract
Particle replication in non-wetting templates (PRINT) is a novel nanoparticle platform that provides compositional flexibility with the ability to specify size and shape in formulating vaccines. The PRINT platform also offers manufacturing and cost advantages over traditional particle technologies. Across multiple antigen and adjuvant formulations, robust antibody and cellular responses have been achieved using PRINT particles in mouse models. Preclinical studies applying PRINT technology in the disease areas of influenza, malaria, and pneumonia are described in this commentary. The proof of principle studies pave the way toward significant cost-effective solutions to global vaccine supply needs.
KEYWORDS:
adjuvant, antigen delivery, conjugate vaccine, nanoparticle, nanotechnology, vaccine
PMID:
24755482
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24755482
Engineered PRINT? nanoparticles for controlled delivery of antigens and immunostimulants.
Beletskii A, Galloway A, Rele S, Stone M, Malinoski F.
Author information
Abstract
Particle replication in non-wetting templates (PRINT) is a novel nanoparticle platform that provides compositional flexibility with the ability to specify size and shape in formulating vaccines. The PRINT platform also offers manufacturing and cost advantages over traditional particle technologies. Across multiple antigen and adjuvant formulations, robust antibody and cellular responses have been achieved using PRINT particles in mouse models. Preclinical studies applying PRINT technology in the disease areas of influenza, malaria, and pneumonia are described in this commentary. The proof of principle studies pave the way toward significant cost-effective solutions to global vaccine supply needs.
KEYWORDS:
adjuvant, antigen delivery, conjugate vaccine, nanoparticle, nanotechnology, vaccine
PMID:
24755482
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24755482