tetano
Editor, Senior Moderator
eNeurologicalSci
. 2021 Mar;22:100294.
doi: 10.1016/j.ensci.2020.100294. Epub 2020 Nov 30.
D-dimer level elevation can aid in detection of asymptomatic COVID-19 presenting with acute cerebral infarction
Takeru Umemura[SUP] 1 [/SUP], Hirohisa Kondo[SUP] 1 [/SUP], Hirotsugu Ohta[SUP] 1 [/SUP], Koichiro Futatsuya[SUP] 2 [/SUP], Takamitsu Mizobe[SUP] 3 [/SUP], Junkoh Yamamoto[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) mainly manifests as a respiratory syndrome, besides causing other complications. Severe COVID-19 may also present with coagulopathy, leading to venous thrombosis and cerebral infarction. Generally, acute stroke is a secondary complication in patients displaying respiratory syndromes. Here, we present a case of acute stroke in an 84-year-old female patient who did not manifest any respiratory symptoms. The patient had no cough or fever before the stroke onset; nevertheless, COVID-19 PCR test was positive. The patient also had markedly elevated serum D-dimer levels. Our findings suggest that coagulopathy can occur even in a patient with asymptomatic COVID-19 infection, and to our knowledge, this is the first report of such a case. We concluded that elevated D-dimer levels can serve as an additional COVID-19 screening tool in stroke patients.
Keywords: COVID-19; Cerebral infarction; Chest CT; D-dimer; PCR.
. 2021 Mar;22:100294.
doi: 10.1016/j.ensci.2020.100294. Epub 2020 Nov 30.
D-dimer level elevation can aid in detection of asymptomatic COVID-19 presenting with acute cerebral infarction
Takeru Umemura[SUP] 1 [/SUP], Hirohisa Kondo[SUP] 1 [/SUP], Hirotsugu Ohta[SUP] 1 [/SUP], Koichiro Futatsuya[SUP] 2 [/SUP], Takamitsu Mizobe[SUP] 3 [/SUP], Junkoh Yamamoto[SUP] 4 [/SUP]
Affiliations
- PMID: 33283061
- PMCID: PMC7703229
- DOI: 10.1016/j.ensci.2020.100294
Abstract
Coronavirus disease 2019 (COVID-19) mainly manifests as a respiratory syndrome, besides causing other complications. Severe COVID-19 may also present with coagulopathy, leading to venous thrombosis and cerebral infarction. Generally, acute stroke is a secondary complication in patients displaying respiratory syndromes. Here, we present a case of acute stroke in an 84-year-old female patient who did not manifest any respiratory symptoms. The patient had no cough or fever before the stroke onset; nevertheless, COVID-19 PCR test was positive. The patient also had markedly elevated serum D-dimer levels. Our findings suggest that coagulopathy can occur even in a patient with asymptomatic COVID-19 infection, and to our knowledge, this is the first report of such a case. We concluded that elevated D-dimer levels can serve as an additional COVID-19 screening tool in stroke patients.
Keywords: COVID-19; Cerebral infarction; Chest CT; D-dimer; PCR.