tetano
Editor, Senior Moderator
Endocr Rev. 2020 Apr 15. pii: bnaa011. doi: 10.1210/endrev/bnaa011. [Epub ahead of print]
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications.
Drucker DJ[SUP]1[/SUP].
Author information
Abstract
Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic and viral infections. The severe acute respiratory syndrome (SARS)-CoV2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding shared disease pathophysiology potentially informing therapeutic choices in individuals with Type 2 diabetes (T2D). Two coronavirus receptor proteins, Angiotensin Converting Enzyme 2 (ACE2) and Dipeptidyl Peptidase-4 (DPP4) are also established transducers of metabolic signals and pathways regulating inflammation, renal and cardiovascular physiology, and glucose homeostasis. Moreover, glucose-lowering agents such as the DPP4 inhibitors, widely used in subjects with T2D, are known to modify the biological activities of multiple immunomodulatory substrates. Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection.
? Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
KEYWORDS:
Angiotensin Converting Enzyme 2; Diabetes; Dipeptidyl Peptidase-4; Obesity; Receptor; Virus
PMID:32294179DOI:10.1210/endrev/bnaa011
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications.
Drucker DJ[SUP]1[/SUP].
Author information
Abstract
Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic and viral infections. The severe acute respiratory syndrome (SARS)-CoV2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding shared disease pathophysiology potentially informing therapeutic choices in individuals with Type 2 diabetes (T2D). Two coronavirus receptor proteins, Angiotensin Converting Enzyme 2 (ACE2) and Dipeptidyl Peptidase-4 (DPP4) are also established transducers of metabolic signals and pathways regulating inflammation, renal and cardiovascular physiology, and glucose homeostasis. Moreover, glucose-lowering agents such as the DPP4 inhibitors, widely used in subjects with T2D, are known to modify the biological activities of multiple immunomodulatory substrates. Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection.
? Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
KEYWORDS:
Angiotensin Converting Enzyme 2; Diabetes; Dipeptidyl Peptidase-4; Obesity; Receptor; Virus
PMID:32294179DOI:10.1210/endrev/bnaa011