tetano
Editor, Senior Moderator
J Clin Virol. 2011 Jun 16. [Epub ahead of print]
Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1.
Renaud C, Kuypers J, Englund JA.
Source
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, P.O. Box 19024, D3-100, Seattle, WA 98109-1024, United States; University of Washington, Molecular Virology Laboratory, 1616 Eastlake Ave East, Suite 320, Seattle, WA 98102-1024, United States; Pediatric Infectious Diseases, Seattle Childrens' Hospital, 4800 Sand Point Way #R5441, Seattle, WA 98105, United States.
Abstract
The emergence of oseltamivir resistance in seasonal and pandemic influenza A/H1N1 has created challenges for diagnosis and clinical management. This review discusses how clinical virology laboratories have handled diagnosis of oseltamivir-resistant H1N1 and what we have learned from clinical studies and case series. Immunocompetent patients infected with oseltamivir-resistant H1N1 have similar outcomes as patients infected with oseltamivir-susceptible H1N1. However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options.
Copyright ? 2011. Published by Elsevier B.V.
PMID:
21684202
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21684202
Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1.
Renaud C, Kuypers J, Englund JA.
Source
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, P.O. Box 19024, D3-100, Seattle, WA 98109-1024, United States; University of Washington, Molecular Virology Laboratory, 1616 Eastlake Ave East, Suite 320, Seattle, WA 98102-1024, United States; Pediatric Infectious Diseases, Seattle Childrens' Hospital, 4800 Sand Point Way #R5441, Seattle, WA 98105, United States.
Abstract
The emergence of oseltamivir resistance in seasonal and pandemic influenza A/H1N1 has created challenges for diagnosis and clinical management. This review discusses how clinical virology laboratories have handled diagnosis of oseltamivir-resistant H1N1 and what we have learned from clinical studies and case series. Immunocompetent patients infected with oseltamivir-resistant H1N1 have similar outcomes as patients infected with oseltamivir-susceptible H1N1. However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options.
Copyright ? 2011. Published by Elsevier B.V.
PMID:
21684202
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21684202