Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

[HenryN]

Re: :::Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza :::

Re: :::Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza :::

This demostrantes the fitness of oseltamivir-resistant H1N1 viruses but it shouldn't be drawn further conclusions that these viruses are more virulent than oseltamivir-susceptible ones.

The patient was very ill with a severe blood disease and infected by other pathogens thus a poor outcome may be due to this complex situation rather than the presence of a H1N1-resistant virus.

Noteworthy, the concurrent emersion of a sub-population of H1N1-oseltamivir and amantadine resistant viruses.

However, it should be noted that the viral load remained high for three weeks due to Tamiflu resistance prior to treatment and amantadine resistance which developed during treatment. Viral load fell to baseline 8 days after Relenza treatment, which began on day 20.

 

[HenryN]

Re: :::Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza :::

Re: :::Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza :::

Updated list of isolates with H274Y

gb|FJ179363.1| Influenza A virus (A/Illinois/15/2007(H1N1)) s... 34.2 2.5
gb|FJ179362.1| Influenza A virus (A/Illinois/16/2007(H1N1)) s... 34.2 2.5
gb|FJ179361.1| Influenza A virus (A/Pennsylvania/13/2007(H1N1... 34.2 2.5
gb|EU914908.1| Influenza A virus (A/Johannesburg/45/2008(H1N1... 34.2 2.5
gb|EU914907.1| Influenza A virus (A/Johannesburg/36/2008(H1N1... 34.2 2.5
gb|EU914906.1| Influenza A virus (A/Johannesburg/35/2008(H1N1... 34.2 2.5
gb|EU914905.1| Influenza A virus (A/Johannesburg/33/2008(H1N1... 34.2 2.5
gb|EU914904.1| Influenza A virus (A/Johannesburg/14/2008(H1N1... 34.2 2.5
gb|EU914903.1| Influenza A virus (A/Johannesburg/21/2008(H1N1... 34.2 2.5
gb|EU914902.1| Influenza A virus (A/CapeTown/26/2008(H1N1)) n... 34.2 2.5
gb|EU914901.1| Influenza A virus (A/Johannesburg/12/2008(H1N1... 34.2 2.5
gb|EU685788.1| Influenza A virus (A/Paris/1170/2008(H1N1)) ne... 34.2 2.5
gb|EU551826.1| Influenza A virus (A/Paris/749/2007(H1N1)) neu... 34.2 2.5
gb|EU551824.1| Influenza A virus (A/Paris/847/2007(H1N1)) neu... 34.2 2.5
gb|EU551821.1| Influenza A virus (A/Paris/963/2008(H1N1)) neu... 34.2 2.5
gb|EU551815.1| Influenza A virus (A/Paris/577/2007(H1N1)) neu... 34.2 2.5
gb|EU551814.1| Influenza A virus (A/Paris/1157/2008(H1N1)) ne... 34.2 2.5
gb|EU551813.1| Influenza A virus (A/Paris/1208/2008(H1N1)) ne... 34.2 2.5
gb|EU551812.1| Influenza A virus (A/Paris/1154/2008(H1N1)) ne... 34.2 2.5
gb|EU551811.1| Influenza A virus (A/Paris/341/2007(H1N1)) neu... 34.2 2.5
gb|EU551810.1| Influenza A virus (A/Paris/910/2007(H1N1)) neu... 34.2 2.5
gb|EU551809.1| Influenza A virus (A/Paris/644/2007(H1N1)) neu... 34.2 2.5
gb|EU887035.1| Influenza A virus (A/South Carolina/01/2008(H1... 34.2 2.5
gb|EU879082.1| Influenza A virus (A/Zhejiang/Xiangshan522/200... 34.2 2.5
gb|EU879064.1| Influenza A virus (A/Gansu/Chenguan/1129/2007(... 34.2 2.5
gb|EU851986.1| Influenza A virus (A/Minnesota/01/2008(H1N1)) ... 34.2 2.5
gb|EU851982.1| Influenza A virus (A/Hawaii/02/2008(H1N1)) seg... 34.2 2.5
gb|EU851980.1| Influenza A virus (A/Hawaii/01/2008(H1N1)) seg... 34.2 2.5
gb|EU779650.1| Influenza A virus (A/North Carolina/02/2008(H1... 34.2 2.5
gb|EU779643.1| Influenza A virus (A/New Jersey/10/2008(H1N1))... 34.2 2.5
gb|EU779641.1| Influenza A virus (A/Memphis/03/2008(H1N1)) ne... 34.2 2.5
gb|EU681266.1| Influenza A virus (A/Bursa-TR/1231/2007(H1N1))... 34.2 2.5
gb|EU681265.1| Influenza A virus (A/Istanbul-TR/1219/2007(H1N... 34.2 2.5
gb|EU681264.1| Influenza A virus (A/Istanbul-TR/1198/2007(H1N... 34.2 2.5
gb|EU681263.1| Influenza A virus (A/Ankara-TR/170/2008(H1N1))... 34.2 2.5
gb|EU681262.1| Influenza A virus (A/Istanbul-TR/111/2008(H1N1... 34.2 2.5
gb|EU702755.1| Influenza A virus (A/Hong Kong/17/2008(H1N1)) ... 34.2 2.5
gb|EU716587.1| Influenza A virus (A/Washington/01/2008(H1N1))... 34.2 2.5
gb|EU716580.1| Influenza A virus (A/Florida/02/2008(H1N1)) se... 34.2 2.5
gb|EU624316.1| Influenza A virus (A/England/557/2007(H1N1)) s... 34.2 2.5
gb|EU570806.1| Influenza A virus (A/Bursa-TR/28/2008(H1N1)) n... 34.2 2.5
gb|EU567014.1| Influenza A virus (A/New Jersey/06/2008(H1N1))... 34.2 2.5
gb|EU567011.1| Influenza A virus (A/Indiana/01/2008(H1N1)) se... 34.2 2.5
gb|EU567009.1| Influenza A virus (A/Arizona/13/2007(H1N1)) se... 34.2 2.5
gb|EU567006.1| Influenza A virus (A/Arizona/14/2007(H1N1)) se... 34.2 2.5
gb|EU566999.1| Influenza A virus (A/Wisconsin/01/2008(H1N1)) ... 34.2 2.5
gb|EU566998.1| Influenza A virus (A/Maryland/04/2007(H1N1)) s... 34.2 2.5
gb|EU566987.1| Influenza A virus (A/New Jersey/20/2007(H1N1))... 34.2 2.5
gb|EU566983.1| Influenza A virus (A/New Jersey/05/2008(H1N1))... 34.2 2.5
gb|EU566977.1| Influenza A virus (A/Pennsylvania/02/2008(H1N1... 34.2 2.5
gb|EU566968.1| Influenza A virus (A/Arizona/15/2007(H1N1)) se... 34.2 2.5
gb|EU516201.1| Influenza A virus (A/New Jersey/16/2007(H1N1))... 34.2 2.5
gb|EU516200.1| Influenza A virus (A/Illinois/10/2007(H1N1)) s... 34.2 2.5
gb|EU516196.1| Influenza A virus (A/Arizona/03/2007(H1N1)) se... 34.2 2.5
gb|EU516148.1| Influenza A virus (A/New Jersey/15/2007(H1N1))... 34.2 2.5
gb|EU516125.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 34.2 2.5
gb|EU516123.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 34.2 2.5
gb|EU516112.1| Influenza A virus (A/Hawaii/21/2007(H1N1)) seg... 34.2 2.5

 

[HenryN]

Re: Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

Roche Announces Tamiflu<SUP>?</SUP> Antiviral Flu Medication in Ample Supply for 2008-2009 Flu Season
​

• - Rapid Response Program Provides Pharmacies Quick Access During Winter Months -​

Nutley, NJ, September 23, 2008 ? Roche announced today that ample supplies of its prescription antiviral medication Tamiflu<SUP>?</SUP> (oseltamivir phosphate) will be widely available throughout the U.S. this flu season. Tamiflu, cited by the Centers for Disease Control and Prevention (CDC) as an important second line of defense against flu, is indicated for the treatment and prevention of influenza in adults and children one year and older.
To help ensure the medication gets to the pharmacies and people who need it, Roche coordinates a rapid response system with distributors nationwide. Through the program, pharmacists can order additional Tamiflu through a toll-free number (1-800-526-0625) and have it delivered within 24 hours by a local distributor.
?We understand that pharmacists do their best to stock appropriate amounts of antiviral medications, such as Tamiflu, for use during flu season,? said Dominick Iacuzio, Ph.D, medical
director at Roche. ?However, the incidence and severity of seasonal flu remains unpredictable from year to year, and some pharmacies still may be faced with greater-than-expected demand during the season.?
Roche also created an early signaling system called FluSTAR? and advises pharmacies when flu may be spreading in their local area.
Antiviral medications, such as Tamiflu, are one of three steps (along with vaccination and good hygiene) outlined in the CDC?s ?Take 3? influenza initiative. Available in a capsule and liquid suspension form, Tamiflu is the only oral antiviral medication recommended by the CDC for influenza treatment and prevention during the 2008-2009 flu season. Unlike the vaccine, which is reformulated each year to work against three specific strains of the virus, Tamiflu is designed to be active against all clinically relevant influenza virus strains.
?Because Tamiflu prevents the influenza virus from spreading inside the body, it has to be given within the first 48 hours of flu symptoms in order to be effective,? said Iacuzio. ?People need to be aware of typical flu symptoms, and call the doctor quickly as soon as symptoms arise, for proper diagnosis.?
While not a substitute for vaccination, prescription antiviral drugs are an important adjunct, offering a second line of defense in preventing and treating seasonal influenza.
Flu Treatment
If a person does contract the virus, antiviral medications are available by prescription to treat the flu. According to the CDC, ?for treatment, influenza antiviral drugs should be started within two days after becoming sick and taken for five days.? Tamiflu can reduce flu symptoms and shorten the time of sickness.
Flu Prevention
Antiviral medications such as Tamiflu can also be given prophylactically to people who have been exposed to influenza to help contain the spread in certain settings, such as family members passing the virus to one another in a household.
Preventive doses of Tamiflu following exposure to the flu can also be considered for controlling outbreaks in closed or semi-closed settings, such as nursing homes or dormitories. Clinical trials indicate that Tamiflu is up to 92 percent effective in preventing flu in adults ? and 82 percent effective in preventing flu in children ? when taken within 48 hours of exposure.
About Tamiflu Tamiflu, co-developed by Gilead Sciences, Inc., based in Foster City, CA, is indicated for the treatment of uncomplicated influenza caused by viruses types A and B in patients one year and older who have had flu symptoms for no more than two days. Tamiflu is also indicated for the prevention of influenza in patients one year and older. Tamiflu is not a substitute for annual early vaccination as recommended by the CDC. Prescribers should consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use Tamiflu.
In post-marketing experience, rare cases of anaphylaxis and serious skin reactions have been reported. There have been post-marketing reports (mostly from Japan) of self-injury and delirium with the use of Tamiflu in patients with influenza. The reports were primarily among children. The relative contribution of the drug to these events is not known. Patients with influenza should be closely monitored for signs of abnormal behavior throughout the treatment period.
The most frequently reported adverse events in clinical studies were nausea, vomiting, and diarrhea. Tamiflu is available for the treatment of influenza in more than 80 countries worldwide. Prescribing information for Tamiflu is available at [URL="http://www.rocheusa.com/products/tamiflu"]www.rocheusa.com/products/tamiflu[/URL].
About Roche
Hoffmann-La Roche Inc. (Roche), in Nutley, N.J., is the U.S. pharmaceuticals headquarters of the Roche Group, a leading, global healthcare company. For more than 100 years, Roche has been developing innovative products and services that address prevention, diagnosis and treatment of disease.
For more information, visit [URL="http://www.rocheusa/"]http://www.rocheusa.com[/URL]. Product and treatment information for U.S. healthcare professionals is available at [URL="http://www.rocheexchange.com/"]www.RocheExchange.com[/URL]. Prescribing information for Tamiflu is available at [URL="http://www.rocheusa.com/products/tamiflu"]www.rocheusa.com/products/tamiflu[/URL].

 

[Giuseppe]

Re: Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

September 29 World Health Organization update at: http://www.flutrackers.com/forum/showthread.php?t=81154

 

[HenryN]

Re: Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

Sequences with H274Y
emb|FM174468.1| Influenza A virus (A/Luxembourg/456/2008(H1N1... 26.3 619
emb|FM174467.1| Influenza A virus (A/Luxembourg/421/2008(H1N1... 26.3 619
emb|FM174466.1| Influenza A virus (A/Luxembourg/402/2008(H1N1... 26.3 619
emb|FM174465.1| Influenza A virus (A/Luxembourg/382/2008(H1N1... 26.3 619
emb|FM174464.1| Influenza A virus (A/Luxembourg/373/2008(H1N1... 26.3 619
emb|FM174463.1| Influenza A virus (A/Luxembourg/285/2008(H1N1... 26.3 619
emb|FM174462.1| Influenza A virus (A/Luxembourg/278/2008(H1N1... 26.3 619
emb|FM174461.1| Influenza A virus (A/Luxembourg/273/2008(H1N1... 26.3 619
emb|FM174460.1| Influenza A virus (A/Luxembourg/265/2008(H1N1... 26.3 619
emb|FM174458.1| Influenza A virus (A/Luxembourg/215/2008(H1N1... 26.3 619
emb|FM174457.1| Influenza A virus (A/Luxembourg/187/2008(H1N1... 26.3 619
emb|FM174456.1| Influenza A virus (A/Luxembourg/182/2008(H1N1... 26.3 619
emb|FM174455.1| Influenza A virus (A/Luxembourg/132/2008(H1N1... 26.3 619
emb|FM174453.1| Influenza A virus (A/Luxembourg/164/2008(H1N1... 26.3 619
emb|FM174430.1| Influenza A virus (A/Luxembourg/022/2008(H1N1... 26.3 619
emb|FM174428.1| Influenza A virus (A/Luxembourg/019/2008(H1N1... 26.3 619
emb|FM174427.1| Influenza A virus (A/Luxembourg/016/2008(H1N1... 26.3 619
emb|FM174426.1| Influenza A virus (A/Luxembourg/006/2008(H1N1... 26.3 619
emb|FM174425.1| Influenza A virus (A/Luxembourg/098/2008(H1N1... 26.3 619
emb|FM174424.1| Influenza A virus (A/Luxembourg/090/2008(H1N1... 26.3 619
emb|FM174423.1| Influenza A virus (A/Luxembourg/086/2008(H1N1... 26.3 619
emb|FM174420.1| Influenza A virus (A/Luxembourg/286/2008(H1N1... 26.3 619
emb|FM174419.1| Influenza A virus (A/Luxembourg/279/2008(H1N1... 26.3 619
emb|FM174418.1| Influenza A virus (A/Luxembourg/261/2008(H1N1... 26.3 619
emb|FM174416.1| Influenza A virus (A/Luxembourg/249/2008(H1N1... 26.3 619
emb|FM174415.1| Influenza A virus (A/Luxembourg/234/2008(H1N1... 26.3 619
emb|FM174414.1| Influenza A virus (A/Luxembourg/222/2008(H1N1... 26.3 619
emb|FM174411.1| Influenza A virus (A/Luxembourg/176/2008(H1N1... 26.3 619
emb|FM174407.1| Influenza A virus (A/Luxembourg/116/2008(H1N1... 26.3 619
emb|FM174406.1| Influenza A virus (A/Luxembourg/115/2008(H1N1... 26.3 619

 

[gsgs]

Re: Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

today at genbank :


these 2 viruses from July 2007
A/Kolkata/975/2007/07(H1N1)
A/Kolkata/985/2007/07(H1N1)
have C439T(8)
(only segments 2(partial) and 8 are given)
this mutation appears together with H274Y(6),
the tamiflu resistance that appeared in H1N1 in Europe in 2008.
This strain is now almost distinct due to the new pandemic.

Another example that new successful strains often
are first seen (emerge ?) in summer in Kolkata/India

and then maybe spread during the monsoon season

 

[gsgs]

Re: Emergence of seasonal influenza viruses type A/H1N1 with oseltamivir resistance in some European Countries at the start of the 2007-8 influenza

I think evidence grows that Tamiflu-resistance was not driven
by drug usage.

---------------------------------------------

I think, we should expand the examination and sequencing of
viruses from India, i.e. Kolkata/West Bengalen in summer.
They are still rare as compared to flu-viruses from other regions
like USA,Europe,Singapore,Japan,HongKong,Australia,New Zealand,
South Korea,
Maybe USA,Europe,WHO,Gates Foundation,... can pay for it ?

If it turns out to be true and maybe monsoon plays a role,
then we could be able to "plant" new strains and mutations,
to "breed" viruses that are less virulent, better managable,
not resistant to drugs.

We could find out in summer, what strains will be circulating in
winter in USA,Europe and improve the vaccine.
Thi vaccine is usually decided in ~April, but maybe we could
improve it, speed up production, and wait until June