tetano
Editor, Senior Moderator
J Virol. 2013 Aug 7. [Epub ahead of print]
Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.
Lohrmann F, Dijkman R, Stertz S, Thiel V, Haller O, Staeheli P, Kochs G.
Source
Institute for Virology, University of Freiburg, 79008 Freiburg, Germany.
Abstract
Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a non-structural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of wild-type A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus out-competed the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.
PMID:
23926347
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23926347
Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.
Lohrmann F, Dijkman R, Stertz S, Thiel V, Haller O, Staeheli P, Kochs G.
Source
Institute for Virology, University of Freiburg, 79008 Freiburg, Germany.
Abstract
Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a non-structural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of wild-type A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus out-competed the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.
PMID:
23926347
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23926347