tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2021 Dec 15;1-12.
doi: 10.1080/22221751.2021.2019560. Online ahead of print.
Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
Zhaoyong Zhang[SUP] 1 [/SUP], Wenkuan Liu[SUP] 1 [/SUP], Shengnan Zhang[SUP] 1 [/SUP], Peilan Wei[SUP] 1 [/SUP], Lu Zhang[SUP] 2 [/SUP], Dehui Chen[SUP] 1 [/SUP], Shuyan Qiu[SUP] 1 [/SUP], Xiaobo Li[SUP] 2 [/SUP], Jingxian Zhao[SUP] 1 [/SUP], Yongxia Shi[SUP] 2 [/SUP], Rong Zhou[SUP] 1 [/SUP], Yanqun Wang[SUP] 1 [/SUP], Jincun Zhao[SUP] 1 3 4 [/SUP]
Affiliations
Abstract
HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
Keywords: HCoV-OC43; hospitalized children; novel genotype; pneumonia; recombinant.
. 2021 Dec 15;1-12.
doi: 10.1080/22221751.2021.2019560. Online ahead of print.
Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
Zhaoyong Zhang[SUP] 1 [/SUP], Wenkuan Liu[SUP] 1 [/SUP], Shengnan Zhang[SUP] 1 [/SUP], Peilan Wei[SUP] 1 [/SUP], Lu Zhang[SUP] 2 [/SUP], Dehui Chen[SUP] 1 [/SUP], Shuyan Qiu[SUP] 1 [/SUP], Xiaobo Li[SUP] 2 [/SUP], Jingxian Zhao[SUP] 1 [/SUP], Yongxia Shi[SUP] 2 [/SUP], Rong Zhou[SUP] 1 [/SUP], Yanqun Wang[SUP] 1 [/SUP], Jincun Zhao[SUP] 1 3 4 [/SUP]
Affiliations
- PMID: 34907853
- DOI: 10.1080/22221751.2021.2019560
Abstract
HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
Keywords: HCoV-OC43; hospitalized children; novel genotype; pneumonia; recombinant.