tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Mar 10;1-41.
doi: 10.1080/22221751.2022.2052358. Online ahead of print.
SARS-CoV-2 reinfection and COVID-19 severity
Nhu Ngoc Nguyen[SUP] 1 2 [/SUP], Linda Houhamdi[SUP] 1 2 [/SUP], Van Thuan Hoang[SUP] 1 3 [/SUP], Jeremy Delerce[SUP] 1 4 2 [/SUP], Léa Delorme[SUP] 1 2 [/SUP], Philippe Colson[SUP] 1 4 2 [/SUP], Philippe Brouqui[SUP] 1 4 2 [/SUP], Pierre-Edouard Fournier[SUP] 1 2 [/SUP], Didier Raoult[SUP] 1 4 2 [/SUP], Philippe Gautret[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied.
Objective: In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection.
Methods: We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files.
Results: A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from March 19, 2020 to August 24, 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate and transfer to ICU when comparing the two episodes of infections.
Conclusion: Our results suggest that the severity of a second episode of COVID-19 is in the same range of that of the first infection, including patients with antibodies.
Keywords: COVID-19; SARS-CoV-2; coronavirus; reinfection; severity.
. 2022 Mar 10;1-41.
doi: 10.1080/22221751.2022.2052358. Online ahead of print.
SARS-CoV-2 reinfection and COVID-19 severity
Nhu Ngoc Nguyen[SUP] 1 2 [/SUP], Linda Houhamdi[SUP] 1 2 [/SUP], Van Thuan Hoang[SUP] 1 3 [/SUP], Jeremy Delerce[SUP] 1 4 2 [/SUP], Léa Delorme[SUP] 1 2 [/SUP], Philippe Colson[SUP] 1 4 2 [/SUP], Philippe Brouqui[SUP] 1 4 2 [/SUP], Pierre-Edouard Fournier[SUP] 1 2 [/SUP], Didier Raoult[SUP] 1 4 2 [/SUP], Philippe Gautret[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35264078
- DOI: 10.1080/22221751.2022.2052358
Abstract
Background: SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied.
Objective: In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection.
Methods: We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files.
Results: A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from March 19, 2020 to August 24, 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate and transfer to ICU when comparing the two episodes of infections.
Conclusion: Our results suggest that the severity of a second episode of COVID-19 is in the same range of that of the first infection, including patients with antibodies.
Keywords: COVID-19; SARS-CoV-2; coronavirus; reinfection; severity.