tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2026 Mar 13:2645856.
doi: 10.1080/22221751.2026.2645856. Online ahead of print.
Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human
Ahmed Kandeil[SUP] 1 2 [/SUP], Pradeep Chopra[SUP] 3 4 [/SUP], Sean D Ray[SUP] 4 5 [/SUP], Balasaheb K Ghotekar[SUP] 3 [/SUP], Charlene Ranadheera[SUP] 6 [/SUP], Trushar Jeevan[SUP] 1 [/SUP], Thomas Fabrizio[SUP] 1 [/SUP], Adam Rubrum[SUP] 1 [/SUP], Geert-Jan Boons[SUP] 3 4 7 8 [/SUP], Stephen Mark Tompkins[SUP] 4 5 [/SUP], Nathalie Bastien[SUP] 6 [/SUP], Richard J Webby[SUP] 1 [/SUP]
Affiliations
Clade 2.3.4.4b A(H5N1) influenza viruses continue to expand their host range and pose increasing public health concerns. A case of severe human infection with genotype D1.1 A(H5N1) with HÀ substitutions was diagnosed in British Columbia. It is important to monitor receptor-binding specificity and antigenicity of emerging variants of circulating influenza A(H5N1) viruses. To evaluate potential human adaptation of this virus, we enriched HA-variant subpopulations and assessed sialic acid receptor usage via glycan microarray, solid-phase assays, and biolayer interferometry. All variants bound exclusively to avian-type sialic acid receptors. The antigenicity of the tested A(H5N1) variants was covered by candidate vaccine viruses.
. 2026 Mar 13:2645856.
doi: 10.1080/22221751.2026.2645856. Online ahead of print.
Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human
Ahmed Kandeil[SUP] 1 2 [/SUP], Pradeep Chopra[SUP] 3 4 [/SUP], Sean D Ray[SUP] 4 5 [/SUP], Balasaheb K Ghotekar[SUP] 3 [/SUP], Charlene Ranadheera[SUP] 6 [/SUP], Trushar Jeevan[SUP] 1 [/SUP], Thomas Fabrizio[SUP] 1 [/SUP], Adam Rubrum[SUP] 1 [/SUP], Geert-Jan Boons[SUP] 3 4 7 8 [/SUP], Stephen Mark Tompkins[SUP] 4 5 [/SUP], Nathalie Bastien[SUP] 6 [/SUP], Richard J Webby[SUP] 1 [/SUP]
Affiliations
- PMID: 41824556
- DOI: 10.1080/22221751.2026.2645856
Clade 2.3.4.4b A(H5N1) influenza viruses continue to expand their host range and pose increasing public health concerns. A case of severe human infection with genotype D1.1 A(H5N1) with HÀ substitutions was diagnosed in British Columbia. It is important to monitor receptor-binding specificity and antigenicity of emerging variants of circulating influenza A(H5N1) viruses. To evaluate potential human adaptation of this virus, we enriched HA-variant subpopulations and assessed sialic acid receptor usage via glycan microarray, solid-phase assays, and biolayer interferometry. All variants bound exclusively to avian-type sialic acid receptors. The antigenicity of the tested A(H5N1) variants was covered by candidate vaccine viruses.