tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Feb 17;1-32.
doi: 10.1080/22221751.2022.2043726. Online ahead of print.
Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
Alexander Postel[SUP] 1 [/SUP], Jacqueline King[SUP] 2 [/SUP], Franziska K Kaiser[SUP] 3 [/SUP], Johanna Kennedy[SUP] 1 [/SUP], Mara Sophie Lombardo[SUP] 4 [/SUP], Wencke Reineking[SUP] 4 [/SUP], Madeleine de le Roi[SUP] 4 [/SUP], Timm Harder[SUP] 2 [/SUP], Anne Pohlmann[SUP] 2 [/SUP], Thomas Gerlach[SUP] 3 [/SUP], Guus Rimmelzwaan[SUP] 3 [/SUP], Simon Rohner[SUP] 5 [/SUP], Lotte Caecilia Striewe[SUP] 5 [/SUP], Stephanie Gross[SUP] 5 [/SUP], Luca A Schick[SUP] 5 [/SUP], Jana C Klink[SUP] 5 [/SUP], Katharina Kramer[SUP] 6 [/SUP], Albert D M E Osterhaus[SUP] 3 [/SUP], Martin Beer[SUP] 2 [/SUP], Wolfgang Baumgärtner[SUP] 4 [/SUP], Ursula Siebert[SUP] 5 [/SUP], Paul Becher[SUP] 1 [/SUP]
Affiliations
Abstract
In brain tissue of three harbor seals of the German North Sea Coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627 K variants detected in these cases.
Keywords: H5N8; HPAIV; avian; brain; influenza virus; lung; mammal; seal.
. 2022 Feb 17;1-32.
doi: 10.1080/22221751.2022.2043726. Online ahead of print.
Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
Alexander Postel[SUP] 1 [/SUP], Jacqueline King[SUP] 2 [/SUP], Franziska K Kaiser[SUP] 3 [/SUP], Johanna Kennedy[SUP] 1 [/SUP], Mara Sophie Lombardo[SUP] 4 [/SUP], Wencke Reineking[SUP] 4 [/SUP], Madeleine de le Roi[SUP] 4 [/SUP], Timm Harder[SUP] 2 [/SUP], Anne Pohlmann[SUP] 2 [/SUP], Thomas Gerlach[SUP] 3 [/SUP], Guus Rimmelzwaan[SUP] 3 [/SUP], Simon Rohner[SUP] 5 [/SUP], Lotte Caecilia Striewe[SUP] 5 [/SUP], Stephanie Gross[SUP] 5 [/SUP], Luca A Schick[SUP] 5 [/SUP], Jana C Klink[SUP] 5 [/SUP], Katharina Kramer[SUP] 6 [/SUP], Albert D M E Osterhaus[SUP] 3 [/SUP], Martin Beer[SUP] 2 [/SUP], Wolfgang Baumgärtner[SUP] 4 [/SUP], Ursula Siebert[SUP] 5 [/SUP], Paul Becher[SUP] 1 [/SUP]
Affiliations
- PMID: 35172704
- DOI: 10.1080/22221751.2022.2043726
Abstract
In brain tissue of three harbor seals of the German North Sea Coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627 K variants detected in these cases.
Keywords: H5N8; HPAIV; avian; brain; influenza virus; lung; mammal; seal.