tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Oct 10;1-32.
doi: 10.1080/22221751.2022.2133639. Online ahead of print.
Healthy Outcomes of Patients with COVID-19 Two Years after the Infection: A Prospective Cohort Study
Dapeng Li[SUP] 1 [/SUP], Xuejiao Liao[SUP] 1 [/SUP], Zhi Liu[SUP] 1 [/SUP], Zhenghua Ma[SUP] 1 [/SUP], Jingke Dong[SUP] 1 [/SUP], Guoqin Zheng[SUP] 1 [/SUP], Mei Zi[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Qing He[SUP] 1 [/SUP], Guobao Li[SUP] 1 [/SUP], Zheng Zhang[SUP] 1 2 3 [/SUP], Lei Liu[SUP] 1 2 [/SUP]
Affiliations
Abstract
The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography (CT) scans, routine laboratory tests. Two years after infection, 36.6% of patients had at least one symptom of long COVID. Vision impairment and fatigue were the most common symptom. 35.0% of participants still had at least one psychological symptom of anxiety, depression, post-traumatic stress symptoms, and sleep difficulties. Radiographic abnormalities were presented in 50.7% of patients, with the most common features of fibrosis-like lesions and residual ground-glass opacity. Diffuse dysfunction (24.0%) was the main abnormalities of pulmonary function tests. Most laboratory parameters returned to normal range, while persistent abnormalities in kidney and liver function test were observed in a subset of participants after discharge. Two years after COVID-19 infection, persistent symptoms of long COVID and psychological symptoms, as well as abnormalities in pulmonary function test and CT, were still common in a subset of recovering individuals. These findings were limited by the lack of a healthy control group and pre-COVID assessments, which should be confirmed by further large-scale studies.
Keywords: COVID-19; SARS-CoV-2; follow-up; long COVID.
. 2022 Oct 10;1-32.
doi: 10.1080/22221751.2022.2133639. Online ahead of print.
Healthy Outcomes of Patients with COVID-19 Two Years after the Infection: A Prospective Cohort Study
Dapeng Li[SUP] 1 [/SUP], Xuejiao Liao[SUP] 1 [/SUP], Zhi Liu[SUP] 1 [/SUP], Zhenghua Ma[SUP] 1 [/SUP], Jingke Dong[SUP] 1 [/SUP], Guoqin Zheng[SUP] 1 [/SUP], Mei Zi[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Qing He[SUP] 1 [/SUP], Guobao Li[SUP] 1 [/SUP], Zheng Zhang[SUP] 1 2 3 [/SUP], Lei Liu[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36215047
- DOI: 10.1080/22221751.2022.2133639
Abstract
The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography (CT) scans, routine laboratory tests. Two years after infection, 36.6% of patients had at least one symptom of long COVID. Vision impairment and fatigue were the most common symptom. 35.0% of participants still had at least one psychological symptom of anxiety, depression, post-traumatic stress symptoms, and sleep difficulties. Radiographic abnormalities were presented in 50.7% of patients, with the most common features of fibrosis-like lesions and residual ground-glass opacity. Diffuse dysfunction (24.0%) was the main abnormalities of pulmonary function tests. Most laboratory parameters returned to normal range, while persistent abnormalities in kidney and liver function test were observed in a subset of participants after discharge. Two years after COVID-19 infection, persistent symptoms of long COVID and psychological symptoms, as well as abnormalities in pulmonary function test and CT, were still common in a subset of recovering individuals. These findings were limited by the lack of a healthy control group and pre-COVID assessments, which should be confirmed by further large-scale studies.
Keywords: COVID-19; SARS-CoV-2; follow-up; long COVID.