tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2024 Aug 15:2392667.
doi: 10.1080/22221751.2024.2392667. Online ahead of print. Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023
Shannon L Russell[SUP] 1 2 [/SUP], Cassandra L Andrew[SUP] 3 [/SUP], Kevin C Yang[SUP] 1 4 [/SUP], Michelle Coombe[SUP] 5 [/SUP], Glenna McGregor[SUP] 5 [/SUP], Tony Redford[SUP] 5 [/SUP], Agatha N Jassem[SUP] 1 2 [/SUP], James E A Zlosnik[SUP] 1 2 [/SUP], Jolene Giacinti[SUP] 6 [/SUP], Kevin S Kuchinski[SUP] 1 [/SUP], John Palmer[SUP] 1 [/SUP], John R Tyson[SUP] 1 2 [/SUP], Chris Fjell[SUP] 1 2 [/SUP], Megan Willie[SUP] 7 [/SUP], Megan V Ross[SUP] 7 [/SUP], Maeve Winchester[SUP] 8 [/SUP], Laurie Wilson[SUP] 7 [/SUP], Yohannes Berhane[SUP] 9 [/SUP], Caeley Thacker[SUP] 8 [/SUP], N Jane Harms[SUP] 10 [/SUP], Catherine Soos[SUP] 6 [/SUP], Theresa Burns[SUP] 5 [/SUP], Natalie Prystajecky[SUP] 1 2 [/SUP], Chelsea Himsworth[SUP] 3 5 11 [/SUP]
Affiliations
Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from September 2022 - June 2023 compared to the first 'wave' of the outbreak in this region, which occurred April - August 2022, after the initial viral introduction. Although the number of HPAI-positive poultry farms and wildlife samples was greater in 'Wave 2', cases were more tightly clustered in southwestern B.C. and the most commonly affected species differed, likely due to an influx of overwintering waterfowl in the area. Eight HPAI genetic clusters, representing seven genotypes and two inter-continental viral incursions, were detected, with significant variation in the relative abundance of each cluster between the waves. Phylogenetic data suggests multiple spillover events from wild birds to poultry and mammals but could not rule out transmission among farms and among mammals.
Keywords: H5N1; HPAI; avian influenza; clade 2.3.4.4b; molecular epidemiology; phylodynamics; surveillance; whole genome sequence.
. 2024 Aug 15:2392667.
doi: 10.1080/22221751.2024.2392667. Online ahead of print. Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023
Shannon L Russell[SUP] 1 2 [/SUP], Cassandra L Andrew[SUP] 3 [/SUP], Kevin C Yang[SUP] 1 4 [/SUP], Michelle Coombe[SUP] 5 [/SUP], Glenna McGregor[SUP] 5 [/SUP], Tony Redford[SUP] 5 [/SUP], Agatha N Jassem[SUP] 1 2 [/SUP], James E A Zlosnik[SUP] 1 2 [/SUP], Jolene Giacinti[SUP] 6 [/SUP], Kevin S Kuchinski[SUP] 1 [/SUP], John Palmer[SUP] 1 [/SUP], John R Tyson[SUP] 1 2 [/SUP], Chris Fjell[SUP] 1 2 [/SUP], Megan Willie[SUP] 7 [/SUP], Megan V Ross[SUP] 7 [/SUP], Maeve Winchester[SUP] 8 [/SUP], Laurie Wilson[SUP] 7 [/SUP], Yohannes Berhane[SUP] 9 [/SUP], Caeley Thacker[SUP] 8 [/SUP], N Jane Harms[SUP] 10 [/SUP], Catherine Soos[SUP] 6 [/SUP], Theresa Burns[SUP] 5 [/SUP], Natalie Prystajecky[SUP] 1 2 [/SUP], Chelsea Himsworth[SUP] 3 5 11 [/SUP]
Affiliations
- PMID: 39143912
- DOI: 10.1080/22221751.2024.2392667
Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from September 2022 - June 2023 compared to the first 'wave' of the outbreak in this region, which occurred April - August 2022, after the initial viral introduction. Although the number of HPAI-positive poultry farms and wildlife samples was greater in 'Wave 2', cases were more tightly clustered in southwestern B.C. and the most commonly affected species differed, likely due to an influx of overwintering waterfowl in the area. Eight HPAI genetic clusters, representing seven genotypes and two inter-continental viral incursions, were detected, with significant variation in the relative abundance of each cluster between the waves. Phylogenetic data suggests multiple spillover events from wild birds to poultry and mammals but could not rule out transmission among farms and among mammals.
Keywords: H5N1; HPAI; avian influenza; clade 2.3.4.4b; molecular epidemiology; phylodynamics; surveillance; whole genome sequence.