tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 May 26;1-20.
doi: 10.1080/22221751.2022.2076613. Online ahead of print.
Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infection
Huang Liang[SUP] 1 [/SUP], Peiyan Zheng[SUP] 1 [/SUP], Qian Wang[SUP] 1 [/SUP], Yijun Deng[SUP] 1 [/SUP], Dan Liang[SUP] 2 [/SUP], Haisu Yi[SUP] 1 [/SUP], Yuanyi Cheng[SUP] 1 [/SUP], Xinwei Zhao[SUP] 3 [/SUP], Jing Ma[SUP] 1 [/SUP], Yidong Yang[SUP] 1 [/SUP], Peiyu Hu[SUP] 4 [/SUP], Pingqian Zheng[SUP] 4 [/SUP], Yudi Zhang[SUP] 3 [/SUP], Shuangshuang Huang[SUP] 1 [/SUP], Xiancheng Lin[SUP] 1 [/SUP], Changwen Ke[SUP] 2 [/SUP], Xuefeng Niu[SUP] 1 [/SUP], Baoqing Sun[SUP] 1 [/SUP], Ling Chen[SUP] 1 3 4 [/SUP]
Affiliations
Abstract
AbstractIn vaccinees who were infected with SARS-CoV in 2003, we observed greater antibody responses against spike and nucleoprotein of both SARS-CoV-2 and SARS-CoV after a single dosage of inactivated SARS-CoV-2 vaccine. After receiving the second vaccination, antibodies against RBD of SARS-CoV-2 Wuhan, Beta, Delta, and recently emerged Omicron are significantly higher in SARS-CoV experienced vaccinees than in SARS-CoV naïve vaccinees. Neutralizing activities measured by authentic viruses and pseudoviruses of SARS-CoV, SARS-CoV-2 Wuhan, Beta, and Delta are greater in SARS-CoV experienced vaccinees. In contrast, only weak neutralizing activities against SARS-CoV-2 and variants were detected in SARS-CoV naïve vaccinees. By 6 months after the second vaccination, neutralizing activities were maintained at a relatively higher level in SARS-CoV experienced vaccinees but were undetectable in SARS-CoV naïve vaccinees. These findings suggested a great possibility of developing a universal vaccine by heterologous vaccination using spike antigens from different SARS-related coronaviruses.
. 2022 May 26;1-20.
doi: 10.1080/22221751.2022.2076613. Online ahead of print.
Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infection
Huang Liang[SUP] 1 [/SUP], Peiyan Zheng[SUP] 1 [/SUP], Qian Wang[SUP] 1 [/SUP], Yijun Deng[SUP] 1 [/SUP], Dan Liang[SUP] 2 [/SUP], Haisu Yi[SUP] 1 [/SUP], Yuanyi Cheng[SUP] 1 [/SUP], Xinwei Zhao[SUP] 3 [/SUP], Jing Ma[SUP] 1 [/SUP], Yidong Yang[SUP] 1 [/SUP], Peiyu Hu[SUP] 4 [/SUP], Pingqian Zheng[SUP] 4 [/SUP], Yudi Zhang[SUP] 3 [/SUP], Shuangshuang Huang[SUP] 1 [/SUP], Xiancheng Lin[SUP] 1 [/SUP], Changwen Ke[SUP] 2 [/SUP], Xuefeng Niu[SUP] 1 [/SUP], Baoqing Sun[SUP] 1 [/SUP], Ling Chen[SUP] 1 3 4 [/SUP]
Affiliations
- PMID: 35615992
- DOI: 10.1080/22221751.2022.2076613
Abstract
AbstractIn vaccinees who were infected with SARS-CoV in 2003, we observed greater antibody responses against spike and nucleoprotein of both SARS-CoV-2 and SARS-CoV after a single dosage of inactivated SARS-CoV-2 vaccine. After receiving the second vaccination, antibodies against RBD of SARS-CoV-2 Wuhan, Beta, Delta, and recently emerged Omicron are significantly higher in SARS-CoV experienced vaccinees than in SARS-CoV naïve vaccinees. Neutralizing activities measured by authentic viruses and pseudoviruses of SARS-CoV, SARS-CoV-2 Wuhan, Beta, and Delta are greater in SARS-CoV experienced vaccinees. In contrast, only weak neutralizing activities against SARS-CoV-2 and variants were detected in SARS-CoV naïve vaccinees. By 6 months after the second vaccination, neutralizing activities were maintained at a relatively higher level in SARS-CoV experienced vaccinees but were undetectable in SARS-CoV naïve vaccinees. These findings suggested a great possibility of developing a universal vaccine by heterologous vaccination using spike antigens from different SARS-related coronaviruses.