tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2026 May;32(5).
doi: 10.3201/eid3205.251926.
Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue
Kenrie P Y Hui, John C W Ho, Ka-Chun Ng, Richard J Webby, Malik Peiris, John M Nicholls, Michael C W Chan
In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.
Keywords: H5N1; Hong Kong; Influenza; cattle influenza; cytokine; ex vivo; human respiratory tract; inflammatory; respiratory infections; viruses; zoonoses.
. 2026 May;32(5).
doi: 10.3201/eid3205.251926.
Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue
Kenrie P Y Hui, John C W Ho, Ka-Chun Ng, Richard J Webby, Malik Peiris, John M Nicholls, Michael C W Chan
- PMID: 41922194
- DOI: 10.3201/eid3205.251926
In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.
Keywords: H5N1; Hong Kong; Influenza; cattle influenza; cytokine; ex vivo; human respiratory tract; inflammatory; respiratory infections; viruses; zoonoses.