tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2022 Oct 3;28(11).
doi: 10.3201/eid2811.220914. Online ahead of print.
TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
Pimpayao Sodsai, Chupong Ittiwut, Vichaya Ruenjaiman, Rungnapa Ittiwut, Watsamon Jantarabenjakul, Kanya Suphapeetiporn, Vorasuk Shotelersuk, Nattiya Hirankarn
Abstract
A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
Keywords: COVID-19; SARS; SARS-CoV-2; T cells; TIGIT; Thailand; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2022 Oct 3;28(11).
doi: 10.3201/eid2811.220914. Online ahead of print.
TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
Pimpayao Sodsai, Chupong Ittiwut, Vichaya Ruenjaiman, Rungnapa Ittiwut, Watsamon Jantarabenjakul, Kanya Suphapeetiporn, Vorasuk Shotelersuk, Nattiya Hirankarn
- PMID: 36191906
- DOI: 10.3201/eid2811.220914
Abstract
A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
Keywords: COVID-19; SARS; SARS-CoV-2; T cells; TIGIT; Thailand; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.