tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Nov 29;28(1).
doi: 10.3201/eid2801.211952. Online ahead of print.
Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain
Cristina Rodríguez-Grande, Luis Alcalá, Agustín Estévez, Pedro J Sola-Campoy, Sergio Buenestado-Serrano, Carolina Martínez-Laperche, Víctor Manuel de la Cueva, Roberto Alonso, Cristina Andrés-Zayas, Javier Adán-Jiménez, Carmen Losada, Carla Rico-Luna, Iñaki Comas, Fernando González-Candelas, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma, Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Abstract
Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. We conducted a systematic study of reinfections in Madrid, Spain, supported by genomic viral analysis and host genetic analysis, to cleanse laboratory errors and to discriminate between reinfections and recurrences involving the same strain. Among the 41,195 cases diagnosed (March 2020-March 2021), 93 (0.23%) had 2 positive reverse transcription PCR tests (55-346 days apart). After eliminating cases with specimens not stored, of suboptimal sequence quality, or belonging to different persons, we obtained valid data from 22 cases. Of those, 4 (0.01%) cases were recurrences involving the same strain; case-patients were 39-93 years of age, and 3 were immunosuppressed. Eighteen (0.04%) cases were reinfections; patients were 19-84 years of age, and most had no relevant clinical history. The second episode was more severe in 8 cases.
Keywords: COVID-19; Madrid; SARS-CoV-2; Spain; coronavirus disease; recurrence; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; variant of concern; variant of interest; viruses; zoonoses.
. 2021 Nov 29;28(1).
doi: 10.3201/eid2801.211952. Online ahead of print.
Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain
Cristina Rodríguez-Grande, Luis Alcalá, Agustín Estévez, Pedro J Sola-Campoy, Sergio Buenestado-Serrano, Carolina Martínez-Laperche, Víctor Manuel de la Cueva, Roberto Alonso, Cristina Andrés-Zayas, Javier Adán-Jiménez, Carmen Losada, Carla Rico-Luna, Iñaki Comas, Fernando González-Candelas, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma, Gregorio Marañón Microbiology-ID COVID 19 Study Group2
- PMID: 34843661
- DOI: 10.3201/eid2801.211952
Abstract
Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. We conducted a systematic study of reinfections in Madrid, Spain, supported by genomic viral analysis and host genetic analysis, to cleanse laboratory errors and to discriminate between reinfections and recurrences involving the same strain. Among the 41,195 cases diagnosed (March 2020-March 2021), 93 (0.23%) had 2 positive reverse transcription PCR tests (55-346 days apart). After eliminating cases with specimens not stored, of suboptimal sequence quality, or belonging to different persons, we obtained valid data from 22 cases. Of those, 4 (0.01%) cases were recurrences involving the same strain; case-patients were 39-93 years of age, and 3 were immunosuppressed. Eighteen (0.04%) cases were reinfections; patients were 19-84 years of age, and most had no relevant clinical history. The second episode was more severe in 8 cases.
Keywords: COVID-19; Madrid; SARS-CoV-2; Spain; coronavirus disease; recurrence; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; variant of concern; variant of interest; viruses; zoonoses.
