Giuseppe
Emeritus
Severe Cases of Pandemic (H1N1) 2009 in Children (Emerg Infect Dis., abstract, edited)
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Jaournal, full text: <cite cite="http://www.cdc.gov/eid/content/17/2/186.htm">Severe Cases of Pandemic (H1N1) 2009 in Children | CDC EID</cite>. Abstract, edited.]
Volume 17, Number 2?February 2011
Research
Severe Cases of Pandemic (H1N1) 2009 in Children, Germany
Mathias Altmann, Lena Fiebig, Jana Soyka, R?diger von Kries, Manuel Dehnert, and Walter Haas
Author affiliations: Robert Koch Institute, Berlin, Germany (M. Altmann, L. Fiebig, J. Soyka, M. Dehnert, W. Haas); and Ludwig-Maximilians-Universit?t, Munich, Germany (R. von Kries)
Abstract
In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having >1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%?21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.
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------<cite cite="http://www.cdc.gov/eid/content/17/2/186.htm"></cite>
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Jaournal, full text: <cite cite="http://www.cdc.gov/eid/content/17/2/186.htm">Severe Cases of Pandemic (H1N1) 2009 in Children | CDC EID</cite>. Abstract, edited.]
Volume 17, Number 2?February 2011
Research
Severe Cases of Pandemic (H1N1) 2009 in Children, Germany
Mathias Altmann, Lena Fiebig, Jana Soyka, R?diger von Kries, Manuel Dehnert, and Walter Haas
Author affiliations: Robert Koch Institute, Berlin, Germany (M. Altmann, L. Fiebig, J. Soyka, M. Dehnert, W. Haas); and Ludwig-Maximilians-Universit?t, Munich, Germany (R. von Kries)
Abstract
In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having >1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%?21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.
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------<cite cite="http://www.cdc.gov/eid/content/17/2/186.htm"></cite>