tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2020 Sep 24;26(12).
doi: 10.3201/eid2612.203309. Online ahead of print.
Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples
Gabriella L Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E Faustini, Edith Marcial-Juarez, Adrian M Shields, Margaret Goodall, Joel D Allen, Yasunori Watanabe, Maddy L Newby, Max Crispin, Mark T Drayson, Adam F Cunningham, Alex G Richter, Matthew K O'Shea
Abstract
Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.
Keywords: COVID-19; DBS; SARS-CoV-2; antibody; coronavirus disease; dried blood spot; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2020 Sep 24;26(12).
doi: 10.3201/eid2612.203309. Online ahead of print.
Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples
Gabriella L Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E Faustini, Edith Marcial-Juarez, Adrian M Shields, Margaret Goodall, Joel D Allen, Yasunori Watanabe, Maddy L Newby, Max Crispin, Mark T Drayson, Adam F Cunningham, Alex G Richter, Matthew K O'Shea
- PMID: 32969788
- DOI: 10.3201/eid2612.203309
Abstract
Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.
Keywords: COVID-19; DBS; SARS-CoV-2; antibody; coronavirus disease; dried blood spot; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.