tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Sep 3;27(12).
doi: 10.3201/eid2712.211465. Online ahead of print.
SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021
Jackie Kleynhans, Stefano Tempia, Nicole Wolter, Anne von Gottberg, Jinal N Bhiman, Amelia Buys, Jocelyn Moyes, Meredith L McMorrow, Kathleen Kahn, F Xavier Gómez-Olivé, Stephen Tollman, Neil A Martinson, Floidy Wafawanaka, Limakatso Lebina, Jacques du Toit, Waasila Jassat, Mzimasi Neti, Marieke Brauer, Cheryl Cohen, PHIRST-C Group
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020-March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection-case, infection-hospitalization, and infection-fatality ratios in 2 waves of infection. Post-second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35-59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35-59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection-fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
Keywords: COVID-19; SARS-CoV-2; South Africa; coronavirus disease; coronaviruses; infection–case ratio; infection–fatality ratio; infection–hospitalization ratio; respiratory infections; seroprevalence; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2021 Sep 3;27(12).
doi: 10.3201/eid2712.211465. Online ahead of print.
SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021
Jackie Kleynhans, Stefano Tempia, Nicole Wolter, Anne von Gottberg, Jinal N Bhiman, Amelia Buys, Jocelyn Moyes, Meredith L McMorrow, Kathleen Kahn, F Xavier Gómez-Olivé, Stephen Tollman, Neil A Martinson, Floidy Wafawanaka, Limakatso Lebina, Jacques du Toit, Waasila Jassat, Mzimasi Neti, Marieke Brauer, Cheryl Cohen, PHIRST-C Group
- PMID: 34477548
- DOI: 10.3201/eid2712.211465
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020-March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection-case, infection-hospitalization, and infection-fatality ratios in 2 waves of infection. Post-second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35-59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35-59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection-fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
Keywords: COVID-19; SARS-CoV-2; South Africa; coronavirus disease; coronaviruses; infection–case ratio; infection–fatality ratio; infection–hospitalization ratio; respiratory infections; seroprevalence; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.