tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2026 May;32(5):794-799.
doi: 10.3201/eid3205.260053.
Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model
Meaghan Flagg, Christopher J Winski, Bridget G Brackney, Tessa R Lutterman, Johan A Ortiz-Morales, Brandi N Williamson, Emmie de Wit
Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and highly pathogenic avian influenza A(H5N1) viruses. Contemporary H5N1 viruses replicated better than the historical isolate; however, interferon response to B3.13 genotype viruses was dampened.
Keywords: H5N1; clade 2.3.4.4b; highly pathogenic avian influenza; influenza; influenza A virus; innate immune response; respiratory infections; upper respiratory tract; virus replication; viruses; zoonoses.
. 2026 May;32(5):794-799.
doi: 10.3201/eid3205.260053.
Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model
Meaghan Flagg, Christopher J Winski, Bridget G Brackney, Tessa R Lutterman, Johan A Ortiz-Morales, Brandi N Williamson, Emmie de Wit
- PMID: 42116615
- DOI: 10.3201/eid3205.260053
Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and highly pathogenic avian influenza A(H5N1) viruses. Contemporary H5N1 viruses replicated better than the historical isolate; however, interferon response to B3.13 genotype viruses was dampened.
Keywords: H5N1; clade 2.3.4.4b; highly pathogenic avian influenza; influenza; influenza A virus; innate immune response; respiratory infections; upper respiratory tract; virus replication; viruses; zoonoses.