tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2020 Jul 29;26(10).
doi: 10.3201/eid2610.202632. Online ahead of print.
Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
Marie K Das, Anu Chaudhary, Andrew Bryan, Mark H Wener, Susan L Fink, Chihiro Morishima
Abstract
Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance.
Keywords: COVID19; IgG; SARS-CoV-2; antibody; coronavirus; coronavirus disease; performance; qualitative results; quantitative results; respiratory infections; screening; serologic analysis; severe acute respiratory syndrome coronavirus 2; standardization; viruses; z-scores; zoonoses.
. 2020 Jul 29;26(10).
doi: 10.3201/eid2610.202632. Online ahead of print.
Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
Marie K Das, Anu Chaudhary, Andrew Bryan, Mark H Wener, Susan L Fink, Chihiro Morishima
- PMID: 32723430
- DOI: 10.3201/eid2610.202632
Abstract
Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance.
Keywords: COVID19; IgG; SARS-CoV-2; antibody; coronavirus; coronavirus disease; performance; qualitative results; quantitative results; respiratory infections; screening; serologic analysis; severe acute respiratory syndrome coronavirus 2; standardization; viruses; z-scores; zoonoses.